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Hemolytic Anemia - Differential Diagnosis Algorithm Hereditary: • Peripheral blood smear + DAT + further History •
Hemolytic Anemia ... Diagnosis Algorithm Hereditary ... → Sickle Cell anemia ... → Hereditary spherocytosis ... Diagnosis #Algorithm #causes
Differential Diagnosis for Hemolytic Anemia Intrinsic Causes: • Enzyme deficiencies ex. G6PD, pyruvate kinase • Hemoglobinopathies
for Hemolytic Anemia ... Intrinsic Causes ... Hereditary spherocytosis ... Intravascular Causes ... #Hemolytic #Anemia
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Causes of Extravascular ... Defects • Hereditary ... spherocytosis • Hereditary ... immune-complex hemolytic anemia ... Diagnosis #Algorithm #Causes
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... Microangiopathic hemolytic anemia ... defects (e.g. hereditary ... Extravascular #Causes ... diagnosis #hematology #anemia
Spherocytes - The arrow points to one of many spherocytes in this photo. The cells have

Causes of spherocyte ... formation include hereditary ... and hemolytic anemias

Classification of Jaundice Unconjugated hyperbilirubinemia (predominantly indirect bilirubin) • Increased bilirubin production (eg, hemolytic anemias, hemolytic reactions,
(eg, hemolytic anemias ... bilirubin) • Hereditary ... cholestasis, and some cases ... miscellaneous causes ... #differential #causes
Causes of Hyperkalemia l. Pseudohyperkalemia A Cellular efflux; thrombocytosis, erythrocytosis, leukocytosis, in vitro hemolysis B.
Causes of Hyperkalemia ... Hereditary defects ... ), sickle cell anemia ... amyloidosis, sickle cell anemia ... Classification #Causes
Clinical Classification of Pulmonary Hypertension 1. Pulmonary arterial hypertension from pulmonary vasculopathy Idiopathic pulmonary arterial hypertension Heritable gene mutations
with or without hereditary ... Chronic hemolytic anemia ... #Differential #Causes
Blurry Vision - Differential Diagnosis Framework Anatomical Approach to Eye Disease: 1. Lids/Lashes 2. Extraocular Muscles/Motility 3. Conjunctiva/Sclera 4. Cornea 5. Anterior
Concussion Other Causes ... Glaucoma • Leber hereditary ... retinopathy (sickle cell anemia ... ophthalmology #causes
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis The most common causes of hyperlactatemia are usually:
Causes of Lactate ... The most common causes ... - Many other causes ... 30mmHg) - Severe anemia ... Propofol • Type B3: Hereditary
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