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Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Causes of Extravascular ... Intravascular Hemolysis ... Defects • Hereditary ... spherocytosis • Hereditary ... Diagnosis #Algorithm #Causes
Hemolytic Anemia - Differential Diagnosis Algorithm Hereditary: • Peripheral blood smear + DAT + further History •
Hemolytic Anemia ... Diagnosis Algorithm Hereditary ... → Hereditary spherocytosis ... Immune mediated hemolysis ... Diagnosis #Algorithm #causes
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Framework for Hemolysis ... Extravascular Causes ... Intravascular Hemolysis ... defects (e.g. hereditary ... Extravascular #Causes
Differential Diagnosis for Hemolytic Anemia Intrinsic Causes: • Enzyme deficiencies ex. G6PD, pyruvate kinase • Hemoglobinopathies
Diagnosis for Hemolytic ... Anemia Intrinsic Causes ... Hereditary spherocytosis ... Intravascular Causes ... udaygulati #Hemolytic
Hemolysis in Hereditary Spherocytosis. Panel A shows the structure of a normal red cell and a
Hemolysis in Hereditary ... deficiencies that cause ... hereditary spherocytosis ... destruction or hemolysis ... Spherocytosis #Hemolysis
Classification of Jaundice Unconjugated hyperbilirubinemia (predominantly indirect bilirubin) • Increased bilirubin production (eg, hemolytic anemias, hemolytic reactions,
production (eg, hemolytic ... anemias, hemolytic ... bilirubin) • Hereditary ... miscellaneous causes ... #differential #causes
Spherocytes - The arrow points to one of many spherocytes in this photo. The cells have

Causes of spherocyte ... formation include hereditary ... spherocytosis and hemolytic

Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Algorithm Vascular Causes ... • Metabolic/Hereditary ... Gilbert's syndrome • Hemolysis ... Bilirubin: RBC (hemolysis ... LDH: Heart, RBC (hemolysis
Inherited Non-hemolytic Disorders of Hyperbilirubinemia == Disorders of Conjugation == Gilbert Syndrome: • 5-10% of the population
Inherited Non-hemolytic ... • Most common hereditary ... without evidence of hemolysis ... and stress may cause
Clinical Classification of Pulmonary Hypertension 1. Pulmonary arterial hypertension from pulmonary vasculopathy Idiopathic pulmonary arterial hypertension Heritable gene mutations
with or without hereditary ... Schistosomiasis - Chronic hemolytic ... #Differential #Causes
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