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diagnosis hematology differential oncology activation algorithm causes chronic cll deficiency erythematosus ferritin hepatorenal hrs iron leukemia lupus lymphocytic macrophage management
Diagnostic Framework for Anemia (Morphological Approach - MCV) Low MCV - <80fL - "Microcytic" • Iron deficiency
of chronic kidney ... disease, Acute ... Alcohol use, Liver disease ... Myelodysplastic syndrome ... diagnosis #causes #hematology
Iron Deficiency Anemia - Differential Diagnosis Algorithm Labs: Ferritin, iron, transferrin, TIBC, TSAT, sTfR • Blood loss:
Iron Deficiency Anemia ... • Blood loss: GI ... Gastrectomy, WHDA syndrome ... Structural: Celiac disease ... Algorithm #ferritin #hematology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Macrophage Activation Syndrome ... Heart, lung, and kidney ... with leukopenia, anemia ... Diagnosis #Management #Hematology ... #Rheumatology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
• Heavy Chain disease ... Scleromyxedema (CNS+GI ... Amyloidosis (CVS+PNS+GI ... (-) hemolytic anemia ... Paraproteinemias #Hematology
Hepatorenal Syndrome (HRS) Definition: • Functional, potentially reversible kidney impairment. • Occurs in advanced liver disease: cirrhosis, severe alcoholic
Hepatorenal Syndrome ... advanced liver disease ... Classification: ... #Hepatorenal #Syndrome ... #Hepatology #Nephrology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Classification: ... pericardial/abd GI ... lymphopenia, low PLT • Anemia ... C4) • ds-DNA: Kidney ... induced SLE • Kidney
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
Polyarteritis Nodosa: - Kidneys ... neuropathy - GI ... Kidneys -> glomerulonephritis ... differential #diagnosis #rheumatology ... #classification
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
cells can indicate disease ... • Neutropenia, anemia ... • Richter’s Syndrome ... acute leukemia • GI ... workup #oncology #hematology
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