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diagnosis management differential lupus arthritis disease druginduced fungal hematology oncology bcnie bloodculture candida candidemia candidiasis canimorsus capnocytophaga cardiology cell chronic
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Erythematosus (SLE ... • Immunologic Workup ... pANCA anti-MPO - Negative ... life-threatening • Treatment ... Management #Summary #rheumatology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
• Immunologic Workup ... • Immunologic Workup ... pANCA anti-MPO - Negative ... life-threatening • Treatment ... comparison #table #rheumatology
Capnocytophaga Pathogen: Capnocytophaga • 9 species, C. canimorsus responsible for the majority of infections • Gram-negative rod,
infections • Gram-negative ... ), Malignancy, SLE ... 13%), Pneumonia, Endocarditis ... Treatment: • 50% ... microbiology #zoonotic #infectiousdiseases
Blood Culture-Negative Infective Endocarditis (BCNIE) Definition: No etiology found after 3 separate blood cultures remain negative for
Infective Endocarditis ... See charts - ... #Infective #Endocarditis ... #differential #workup ... #infectiousdiseases
Candidemia Workup and Management - IDSA Guidelines 1) Antibiotics • Empiric: Echinocandins (e.g. micafungin) for most patients
Candidemia Workup ... Susceptibilities, Negative ... clinical concern for endocarditis ... Additional metastatic workup ... #candidiasis #treatment
IgG4-Related Disease Clinical history: Man, 60 years, multiorgan involvement, unique or multiple inflammatory pseudotumor 4 phenotypes: •
• Some false negative ... with response to treatment ... IgG4+ cells" Treatment ... management #phenotypes #workup ... #treatment #rheumatology
Coccidiomycosis - Diagnosis Diagnosis: • Mildly elevated peripheral WBC, Eosinophilia (25%), Elevated ESR, Procalcitonin normal (95%) •
trend response to treatment ... Culture (ElA may be negative ... Coccidioides #Diagnosis #workup ... #infectiousdiseases
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
Rheumatology Workup ... erythematosus (SLE ... ANAs; thus, a negative ... Arthritis #laboratory #workup ... diagnosis #testing #Rheumatology
Approach to Joint Pain - Arthritis Differential Diagnosis Framework Inflammatory Versus Noninflammatory Pain • Is it inflammatory
- Autoimmune Rheumatologic ... • Bacterial endocarditis ... aureus • Gram-negative ... arthritis • SLE ... Symmetrical: • RA • SLE
Endocarditis - Overview and Differential Diagnosis Framework Who? Infectious: • Pre-existing valvular disease • Prosthetic valve • Congenital heart disease • IV
• Autoimmune (SLE ... aureus, Coagulase-negative ... staphylococci Culture Negative ... hematuria, + RF Treatment ... Diagnosis #cardiology #infectiousdiseases
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