190 results
Type I Hypersensitivity: Pathogenesis and clinical findings
Definition: Production of lgE Antibodies that bind to harmless allergens
leading to an allergic ... Sensitization" to Allergen ... Initial exposure to allergen ... after clearance of allergen ... within them (i.e. histamine
Effects of H1 Antihistamines at Histamine, Adrenergic, Cholinergic, and Serotonin-Binding Receptors
Cholinergic - Incr Dry mouth, Incr
Antihistamines at Histamine ... Incr Appetite Histamine ... H1 - Decr Allergic
Allergic Rhinitis: Pathogenesis and clinical findings

1. Allergy Sensitization -> Antigen Exposure -> APC (macrophages, HLA class
Allergic Rhinitis ... Allergy Sensitization ... mediators: preformed (histamine ... Tissue edema #Allergic
There are 2 Major Types of Angioedema:
 - Mast cell / histamine mediated – usually presents
- Mast cell / histamine ... angioedema AND allergic ... presents WITHOUT allergic
Summary table of types of hypersensitivity reactions. 
Type 1
 - Mediators: lgE
 - Antigen Form: Soluble
Mechanism of Action: Allergen-specific ... degranulation releasing histamine ... reactions #types #allergy
Basophilia - Differential Diagnosis Framework

Basophils < 1% of the total white blood cell count
Basophils function similarly
cells- contain histamine ... released during an allergic
Bradykinin-mediated Angioedema
Clinical features: Submucosal oedema (face, extremity, genitalia), Laryngeal dyspnea (25% of deaths), Recurrent attacks of
Bradykinin vs. histamin-mediated ... mediated #Angioedema #allergy
Pharmacology: Anti-Allergic Therapy

#Pharmacology #Mechanisms #Allergy #Antiallergic #AntiAllergen #Antihistamines #Leukotrienes
Pharmacology: Anti-Allergic ... Pharmacology #Mechanisms #Allergy
Sleep
Regulation of sleep is critical for life! Ever wonder why you can’t fall asleep while hungry
hungry or why anti-histamines ... #Sleep #anti-histamine
Hypersensitivity: Summary
Type I Hypersensitivity:
 • Immunological Mediator: lgE
 • Immunological Target: Allergen Molecules
 • Ex: Antibiotic
Immunological Target: Allergen ... fever, Urticaria, Allergic ... Immunological Target: Allergen ... Hypersensitivity #Allergy ... #Allergic #Reactions