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management diagnosis algorithm pharmacology clinical syndrome differential table medications gastroenterology neurology hematology cardiology pathophysiology rheumatology infectiousdiseases pulmonary idsa disease comparison
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Macrophage Activation ... soluble CD163 • Histopathologic ... bone marrow Histopathologic ... Treatment: • Corticosteroids ... MAS #Macrophage #Activation
Anaphylaxis: Pathogenesis Anaphylaxis is a Type 1 hypersensitivity reaction While the primary mechanism of anaphylaxis is mast cell
anaphylaxis is mast cell activation ... Inappropriate mast cell activation ... cells • ANS activation
The parasympathetic and sympathetic systems - Activation and inhibition pathways by organ system #Sympathetic #Parasympathetic #Systems #Pathways
sympathetic systems - Activation
Fibrinolysis. Fibrinolysis occurs when plasminogen is activated to plasmin under the influence of factors such as
tissue plasminogen activator ... thrornbolytic drugs by activating
Transplant Infections Timeline Pre-transplant: • Common bacteria (endogenous): Staphylococci (skin), Gram-negative bacilli (gut) • Viruses: HSV (reactivation) Engraftment:
Viruses: HSV (reactivation ... Viruses: HSV (reactivation ... Viruses: CMV (reactivation ... ), VZV (reactivation ... ), CMV (reactivation
IgA Vasculitis – Henoch Scholein Purpura: Pathogenesis and Clinical Findings - Infectious Agents - 50% have
tissue site - Activation ... Leukocytoclastic vasculitis (histopathologic
Hansen's Disease (Leprosy) • Transmission - not completely understood, ?nasal droplets • Symptoms appear ~5 years
chemotherapy, SOT, HIV) Histopathologic ... and numerous AFB Treatment ... diagnosis #management #treatment
Tranexamic Acid - Indications and Pharmacology Pharmacokinetics: • MOA: Inhibits plasminogen activation to plasmin & inhibits fibrinolysis
Inhibits plasminogen activation ... reduces complement activation
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
→Activation of CD8 ... IFN-y) → Excessive activation ... Unknown cause Treatment ... diagnosis #management #treatment
Gastric Intestinal Metaplasia (GIM) • GIM is a precancerous, histopathologic change characterized by replacement of normal
precancerous, histopathologic
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