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diagnosis hemolytic causes algorithm hemolysis intravascular agglutinin calculation classification cold disease index management pmr polymyalgia production reticulocyte rheumatica rheumatology testing
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Microangiopathic hemolytic anemia ... spherocytosis) • Infections ... #Causes #differential ... #diagnosis #hematology ... #anemia
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Hemolysis - Differential ... circulation - Infections ... immune-complex hemolytic anemia ... #Differential #Diagnosis ... Algorithm #Causes #Hematology
Differential Diagnosis for Hemolytic Anemia Intrinsic Causes: • Enzyme deficiencies ex. G6PD, pyruvate kinase • Hemoglobinopathies
Differential Diagnosis ... for Hemolytic Anemia ... drug induced • Infections ... Bartonella, Babesia ... classification #hematology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
B12, Folate • Hormone ... (e.g. cancer, infection ... G6PD deficiency), Infections ... Production #Index #hematology ... #anemia #differential
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... - Differential ... inclusions - If infection ... (oroya fever), babesia ... Algorithm #workup #hematology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
• Symptoms of anemia ... • hemolytic anemia ... younger pts) Differential ... the RBCs causing intravascular ... #hematology #diagnosis
Polymyalgia Rheumatica (PMR) Diagnosis and Management Summary WHAT? • Polymyalgia rheumatica (PMR) is a common systemic inflammatory
hypothyroidism, infection ... • Normocytic anemia ... thyroid-stimulating hormone ... normal and can help differentiate ... Diagnosis #Management #Rheumatology
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