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diagnosis hematology anemia algorithm agglutinin aiha alopecia atypical autoimmune calculation causes classification cold disease framework hair hairloss index loss lymphocytosis
Autoimmune Hemolytic Anemia (AIHA) WARM AHA - Primary - Idiopathics - Secondary Infectious • Viral- HIV, EBV, HCV, HEV •
Autoimmune Hemolytic ... - Secondary Infectious ... • Viral- HIV, ... • Parasitic- Babesia ... AIHA #Diagnosis #Differential
Differential Diagnosis for Hemolytic Anemia Intrinsic Causes: • Enzyme deficiencies ex. G6PD, pyruvate kinase • Hemoglobinopathies
Differential Diagnosis ... for Hemolytic Anemia ... drug induced • Infections ... Bartonella, Babesia ... classification #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
- Differential ... inclusions - If infection ... (oroya fever), babesia ... #Anemia #Differential ... Algorithm #workup #hematology
Causes of Thrombocytopenia - Differential Diagnosis Framework Decreased Production: - Drugs (chemo, yang, sulfa, acetaminophen, NSAIDs, quinine,
Thrombocytopenia - Differential ... etc) - Viral: HIV ... Parasitic: Malaria, babesia ... infiltration: malignancy, infection ... Diagnosis #Framework #hematology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
B12, Folate • Hormone ... (e.g. cancer, infection ... Microangiopathic hemolytic ... G6PD deficiency), Infections ... #anemia #differential
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
- Due to Viral infection ... Diagnosis: • hemolytic ... Mycoplasma, EBV, HIV ... younger pts) Differential ... #anemia #hematology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... DIC/TTP/HUS - Hemolytic ... SLE) - Viral infections ... APLS • Acute Infectious ... • HCV, HBV Not
Reactive or "Atypical" Lymphocytosis Infection • Viral: EBV, CMV, HIV, Herpes viruses, Influenza, Varicella, HTLV-I • Bacterial:
Lymphocytosis Infection ... Viral: EBV, CMV, HIV ... Toxoplasmosis, Babesia ... Lymphocytosis #differential ... #diagnosis #hematology
Allopecia - Differential Diagnosis Framework for Hair Loss Localized / Focal Hair Loss Pattern: • Scarring Alopecia:
Allopecia - Differential ... restriction) • Hormonal ... Dermatitis (Consider HIV ... loss #alopecia #Differential ... #Diagnosis #dermatology
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