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diagnosis hemolytic mgus agglutinin aiha autoimmune behcet calculation chronic classification clinical cll cold gammopathies gammopathy gap globulin hemeonc hodgkins index
Monoclonal Gammopathy of Clinical Significance (MGUS) - Differential Diagnosis Neurologic-Centered: (+) Systemic Features: POEMS, AL amyloid, Cryoglobulinemia
Significance (MGUS) - Differential ... immunotactoid GN, Type I cryo ... Ig deposition disease ... #Diagnosis #hematology ... #oncology
Multiple Myeloma and Monoclonal Gammopathies C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN R
Multiple Myeloma and Monoclonal ... ULN R - Renal disease ... 40 ml/min A - Anemia ... MGUS #diagnosis #hematology ... #oncology
Autoimmune Hemolytic Anemia (AIHA) Treatment Warm AIHA: 1) Steroids - 1-2 mg/kg prednisone daily • Until
Autoimmune Hemolytic Anemia ... esp if severe disease ... underlying condition • Monoclonal ... AIHA #Treatment #management ... #hematology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
Index < 2: • Anemia ... B12, Folate • Hormone ... Chronic kidney disease ... Production #Index #hematology ... #anemia #differential
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
• Symptoms of anemia ... • hemolytic anemia ... younger pts) Differential ... #hemolytic #anemia ... #hematology #diagnosis
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
chemotherapy for low-risk disease ... fludarabine) 3) Monoclonal ... Lymphocytic #Leukemia #oncology ... #hematology #hemeonc ... #diagnosis #management
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
• Heavy Chain disease ... (-) hemolytic anemia ... Paraproteinemias #Hematology ... #Monoclonal #Differential ... #Diagnosis #Oncology
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
Syndrome Systemic disease ... ) Differential Diagnosis ... : monoclonal TNF-aIpha ... Syndrome #diagnosis #management ... signs #symptoms #rheumatology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
Weight loss • Anemia ... Immunohistochemical studies (to differentiate ... number of sites of disease ... classification #hematology ... #oncology #management
Polymyalgia Rheumatica (PMR) Diagnosis and Management Summary WHAT? • Polymyalgia rheumatica (PMR) is a common systemic inflammatory
Diagnosis and Management ... • Normocytic anemia ... thyroid-stimulating hormone ... normal and can help differentiate ... #Rheumatology
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