49 results
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis vs Tumor Lysis ... Cytoreduction with hydroxyurea ... rasburicase Tumor Lysis ... Pathophysiology: Lysis ... Leukostasis #Tumor #Lysis
Hydroxyurea - Pathophysiology and Benefits in Sickle Cell Disease
 • Decreases number of pain crises (
Hydroxyurea - Pathophysiology ... decreased mortality #Hydroxyurea
Hyperviscosity Syndrome - Causes and Treatment

 - Waldenstrom macroglobulinemia (most common) / Plasmapheresis 
 - Multiple
Leukapheresis + Hydroxyurea ... Leukapheresis + Hydroxyurea
Medications for the Management of Anemia

TREATMENT OF ANEMIA
 - Cyanocobalamin/B12
 - Erythropoietin/epoetin alfa
 - Darbepoetin alfa
CELL ANEMIA - Hydroxyurea
Hyperphosphatemia - Differential Diagnosis Algorithm
Transcellular Shift:
 • Rhabdomyolysis
 • Tumor Lysis
 • Metabolic or Respiratory Acidosis
Rhabdomyolysis • Tumor Lysis ... Hyperlipidemia • Tumor Lysis
Tumor lysis syndrome (TLS) - Pathophysiology:
→ Massive tumor cell lysis
→ Release of large amounts of K+,
Tumor lysis syndrome ... Massive tumor cell lysis
Pathophysiology of Tumor Lysis Syndrome (TLS)
Tumor Cell Lysis
-> Release of DNA
 • Purines -> Hypoxanthine /
Pathophysiology of Tumor Lysis ... TLS) Tumor Cell Lysis
Tumor Lysis Syndrome - Workup and Management

Initial workup: BMP, Serum uric acid, LDH, Urine output, Consider
Tumor Lysis Syndrome ... transfer • Tumor lysis ... #TLS #Tumor #Lysis
Hyperkalemia - Differential Diagnosis - Impaired Excretion vs Redistribution

Impaired Urinary Excretion 
 - Renal failure
 -
Hypoaldosteronism Cell Lysis
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV

Microcytic (MCV < 80) "TAILS":
 • Thalassemia
., hydroxyurea,