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hematology hemolytic oncology rheumatology arterial bruising dermatologic embolism gpa granulomatosis hemolysis intravascular lymphoma management mds myelodysplasia myelodysplastic nonpalpable palpable pathophysiology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Causes Intravascular ... thrombocytopenic purpura ... (TTP), Hemolytic ... #Causes #differential ... #diagnosis #hematology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... Diagnosis Framework ... - Hemolytic anemia ... #Differential # ... Diagnosis #hematology
Differential Diagnosis for Hemolytic Anemia Intrinsic Causes: • Enzyme deficiencies ex. G6PD, pyruvate kinase • Hemoglobinopathies
Differential Diagnosis ... : TTP, HUS, DIC, ... Diagnosis #causes ... #classification ... #hematology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
Weight loss • Anemia ... ) Classification ... Lymphoma Workup ... Immunohistochemical studies (to differentiate ... #classification
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA) Skin involvement in granulomatosis with polyangiitis (GPA) is common and
GPA causes disease ... reticularis Differential ... • Goodpasture syndrome ... Necrotising vasculitis, extravascular ... #rash #diagnosis
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
TTP - Laboratory ... Thrombocytopenic Purpura ... WBC count and differential ... impairment #TTP ... #Workup #Hematology
Causes of Purpura or Easy Bruising in Children Platelet count reduced, i.e. thrombocytopenia - Increased platelet destruction
Causes of Purpura ... Immune - ITP ... #Bruising #Causes ... peds #pediatrics #diagnosis ... #differential #
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework VENOUS THROMBOSIS • Acquired Risk Factors: - >48 hours
Diagnosis Framework ... Hyperviscosity, TTP ... • Nephrotic Syndrome ... coagulation and other causes ... of purpura fulminans
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... Thrombocytopenia (ITP ... Workup: • Complete ... blood count with differential ... #diagnosis #hematology
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