15 results
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
lymphoid malignancy (CLL ... malignancies - B-cell ... malignancies -> CLL ... significance (MGUS), CLL ... #anemia #hematology
Hemolysis - Diagnostic Algorithm and Causes

Increased red cell production: 
 • Increased Reticulocytosis/polychromasia 
 • Erythroid
Increased red cell ... Increased red cell ... #Hemolytic #Anemia ... #Algorithm #Differential ... #Hematology #Diagnosis
Causes of Neutropenia with Pancytopenia - Differential Diagnosis Algorithm
Sequestration:
 • Splenomegaly
Marrow Infiltration:
 • Hematologic and non-hematologic
with Pancytopenia ... - Differential ... Myelofibrosis Stem cell ... Toxins • Aplastic Anemia ... #Hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
) (e.g. lupus, CLL ... . primary cold agglutin ... Hemoglobinopathies (e.g. sickle cell ... #differential # ... diagnosis #hematology
Multiple Myeloma and Monoclonal Gammopathies
C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN
R
40 ml/min A - Anemia ... marrow plasma cell ... , B and T cell lymphoproliferative ... MGUS #diagnosis #hematology ... #oncology
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm
Extravascular - Spleen and RES-mediated hemolysis
 -
Causes of Extravascular ... - Differential ... • Sickle cell ... anemia • ... #Hematology
Hemolytic Anemia - Differential Diagnosis Algorithm
 • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... Consider sickle cell ... Agglutination - Cold agglutinins ... #Anemia #Differential ... Algorithm #workup #hematology
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm
Reactive:
 - Systemic Inflammatory
     •
Causes of Diffuse ... Lymphoblastic Leukemia (Pancytopenia ... Lymphocytes) - Monoclonal ... Reed-Sternberg Cells ... #Hematology #Oncology
Skin Ulcers by Etiology - Differential Diagnosis Algorithm
Physical:
 • Trauma
 • Pressure
 • Radiation
Vascular:
 • Arterial
: • Squamous cell ... carcinoma • Basal cell ... fungoides (cutaneous T-cell ... : • Sickle Cell ... #dermatology #Differential
Monoclonal Gammopathy of Undetermined Significance (MGUS) - Summary Framework

Hematologic disorder characterized by the presence of either
No evidence of anemia ... damage, such as hyperCalcemia ... to the plasma cell ... #Significance #hematology ... #diagnosis #oncology