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diagnosis management pharmacology algorithm cardiology comparison hematology product reactions treatment anesthesia anesthesiology binding bradycardia checklist crystalloids digoxin effects elevated evaluation
Causes of Hypercalcemia Hypercalcemia due to increased bone Ca2+ resorption: • Primary hyperparathyroidism, Malignancy, Pseudohyperparathyroidism, Renal failure,
Causes of Hypercalcemia ... Hypercalcemia ... Immobilization Hypercalcemia ... #Causes #differential ... #high #endocrinology
Hypercalcemia Workup and Differential Diagnosis Framework 1) Determine whether PTH-dependent 2) Assess for other hormonal causes 3) Assess for
Hypercalcemia Workup ... uw_IMresidency #Hypercalcemia ... #Workup #Differential ... Diagnosis #algorithm #endocrinology ... #calcium
Hypercalcemia - Differential Diagnosis Algorithm Elevated PTH (High or normal): • Primary Hyperparathyroidism • Familial Hypocalciuric Hypercalcemia Low
Hypercalcemia - ... Elevated PTH (High ... Hypocalciuric Hypercalcemia ... Thiazides/Lithium #Hypercalcemia ... #endocrinology
Hypercalcemia Evaluation 1) Clinical clues - Is the patient symptomatic? - Family history? - Have you done
Hypercalcemia Evaluation ... PTH - Frankly high ... BrighamChiefs #Hypercalcemia ... #workup #differential ... #calcium #elevated
Potassium-Binding Agents to Treat Hyperkalemia Sodium zirconium cyclosilicate (Lokelma): • Mechanism: Preferentially captures K in exchange for
Agents to Treat Hyperkalemia ... magnesium, and calcium ... patients sensitive to high ... Potassium #Binding #Hyperkalemia ... #pharmacology #table
Hypomagnesemia - Etiologies by Mechanism Decreased GI Uptake - Poor dietary intake (particularly common in alcoholics)
abnormalities - Hypercalcemia ... Hypomagnesemia #Differential ... Low #Magnesium #Table ... #Classification ... #Causes #Workup
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary Causes of Rhabdomyolysis: • Trauma: - Immobilization - Crush injury - Compartment
• LDH ↑ • Hyperkalemia ... /Late - Hypercalcemia ... UA positive for blood ... potassium and calcium ... Dialysis for severe hyperkalemia
Causes of Secondary Hypertension - Workup and Differential Diagnosis Approach (when evaluation should be done): 1. Severe or
Hypertension - Workup ... and Differential ... Vasculitis • Endocrinologic ... Hyperthyroidism, Hypercalcemia ... #causes #Differential
Lactated Ringers (LR) vs Normal Saline (NS) - Comparison Composition of LR: • Sodium 130 mEq/L •
Can give with blood ... Is Dangerous in Hyperkalemia ... shift • Saline Causes ... densa receives high ... • Saline May Cause
Digoxin Pharmacology and Pathophysiology 1) Na/K ATPase Pump - Digoxin works by directly binding to and inhibiting
Pump - Digoxin works ... causes: - Increased ... - Hyperkalemia ( ... high potassium levels ... Because digoxin binds
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