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diagnosis liver transaminitis causes hepatitis albumin gradient management saag abnormal alcoholic chemistry drug druginduced effusion elevated function gastroenterology hepatocellular idiosyncratic
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
) - Differential ... • NAFLD • Cirrhosis ... (>1000): • DILI ... Drug-induced liver injury ... Diagnosis #hepatology
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
dose dependent injury ... Chronic - ongoing ↑ LFTs ... Idiosyncratic #differential ... gastroenterology #algorithm ... gastroenterology #hepatology
Diagnosis of ascites according to the serum ascites albumin gradient (SAAG) SAAG ≥ 1.1: - Ascitic protein
Diagnosis of ascites ... protein ≤ 2.5 g/dL: Cirrhosis ... albumin #gradient #hepatology ... #differential # ... diagnosis #algorithm
Ascites Differential Diagnosis Table - Serum Ascites Albumin Gradient (SAAG) SAAG ≥ 1.1: • Cirrhosis • Portal
Ascites Differential ... Diagnosis Table ... SAAG ≥ 1.1: • Cirrhosis ... #Differential # ... Gradient #SAAG #hepatology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Induced Liver Injury ... Diagnosis Algorithm ... disorder (e.g. ascites ... #Diagnosis #Algorithm ... #hepatology
Causes of Ascites - Differential Diagnosis Algorithm Portal Hypertension - Prehepatic: • Portal vein thrombosis • Splenic
- Differential ... Diagnosis Algorithm ... - Hepatic: • Cirrhosis ... #Differential # ... #Hepatology #causes
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
Patterns of Liver Injury ... CMV), Alcoholic cirrhosis ... Patterns #Liver #Injury ... #hepatology #LFTs ... transaminitis #differential
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Liver Enzymes - Differential ... Diagnosis Algorithm ... Infiltrative • Cirrhosis ... • Others #LFTs ... #Hepatology #LiverEnzymes
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
- Differential ... Diagnosis Algorithm ... • Iatrogenic: DILI ... hepatitis: < 1 • Cirrhosis ... #hepatology
Hepatocellular Liver Injury - Differential Diagnosis Framework: Liver Injury → liver test abnormalities without evidence of liver
- Differential ... #Differential # ... Diagnosis #hepatology ... #algorithm #Transaminitis ... #LFTs #hepatitis
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