21 results
Causes of Hypocomplementemia - CHAMPS Mnemonic
C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis
H - Heavy Chain deposition
Causes of Hypocomplementemia ... S - Systemic Lupus ... @AnnKumfer #Hypocomplementemia ... #Low #Complement
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
pathophysiologic causes ... staining): • Low Complement ... Post-strep GN, Lupus ... Nephritis, Cryoglobulinemia ... differential #diagnosis #algorithm
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary
 • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... nephritis, NPSLE ... • Immunologic Workup ... Positive in 60-80% of cases ... 80% - Low complement
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
• Immunologic Workup ... 90% - Low complement ... Discontinuation of causal ... nephritis, NPSLE ... • Immunologic Workup
Causes of Hematuria - Differential Diagnosis Algorithm
Red blood cells on urine microscopy. Must exclude false positives
Differential Diagnosis Algorithm ... • Hereditary nephritis ... IgA, post-strep, lupus ... and >3.5g/day (nephrotic ... glomerulonephritis • Lupus
Eosinophil Disorders Testing Algorithm
INDICATIONS FOR TESTING:
 • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
Algorithm INDICATIONS ... evaluation or workup ... 1,500 cells/µL Workup ... for secondary causes ... eosinophilia (common causes
Hypereosinophilia Different Diagnosis and Workup
Secondary causes are broad so start with a med review, the most
Diagnosis and Workup ... Secondary causes ... the most common cause ... the US inpatient setting ... #algorithm
Causes of Acute Kidney Injury (AKI) - Differential Diagnosis Algorithm
Acute Kidney Injury (AKI) - Acute increase
Differential Diagnosis Algorithm ... IgA, post-strep, lupus ... Acute Interstitial Nephritis ... legionella) • Immune (lupus ... #Causes
Suggested diagnostic approach to a patient with exudative ascites. Low ascitic fluid protein should direct practitioners
syndrome as a cause ... Although nonhepatic causes ... obstruction, nephrotic ... ascites #diagnosis #workup ... #algorithm #differential
Hematuria Workup and Diagnosis Algorithm
 • Confirm hematuria → Urinalysis >3 RBCs/HPF, exclude mimics, repeat testing
Hematuria Workup ... and Diagnosis Algorithm ... mimics, repeat testing ... Nephrology if cause ... #Workup #urology