9 results
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
Rapidly Progressive ... staining): • Low Complement ... Glomerulonephritis #Vasculitis ... #differential #diagnosis ... #algorithm #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
- Differential Diagnosis ... proteinuria, rapidly progressing ... often involved • Hypocomplementemic ... Urticaria and hypocomplementemia ... against MPO • Complement
Pulmonary Renal Syndromes and Mimics - Differential Diagnosis Framework
Diffuse alveolar hemorrhage + rapidly progressive glomerulonephritis
90%:
 -
- Differential Diagnosis ... hemorrhage + rapidly progressive ... anti-GBM) 10%: - Low Complement ... - Normal Complement ... #Differential #Diagnosis
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
Diagnosis Framework ... proteinuria, Rapidly progressing ... Differential Diagnosis ... Elevated AST ALT • Hypocomplementemia ... ) • Hypocomplementemic
Cough - Diagnostic Schema

Infectious: URTI, LRTI, Bacterial, Viral
Irritant/Exposure: Allergic, Post-infectious, Pneumonitis, ACEi, PTX, Foreign Body
Airway Disease:
Cough - Diagnostic ... Irritant/Exposure: Allergic ... CHF, Autoimmune Vasculitis ... Ndouthit #Cough #Diagnosis ... #Differential #Algorithm
Complement 1 esterase inhibitor (C1-INH) Deficiency Testing Algorithm
INDICATIONS FOR TESTING:
 • Recurrent angioedema (without urticaria)
 •
Complement 1 esterase ... Deficiency Testing Algorithm ... ARUPLabs #C1INH #Complement ... Deficiency #Testing #Algorithm ... #allergy #diagnosis
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm

Peripheral Smear concerning for malignancy?
- Differential Diagnosis ... Algorithm Peripheral ... Rheumatologic, Vasculitides ... post-splenectomy, Exercise, Allergic ... #Algorithm #hematology
IGG-4 RELATED DISEASE

WHAT?
 • A chronic, immune-mediated fibroinflammatory disease with tumefactive infiltration of IgG4+ plasma cells
inflammation -> progressive ... aortitis, mimics vasculitis ... breast, skin DIAGNOSIS ... - ↑ IgE, ↓ complement ... #IGG-4 #IGG4 #Diagnosis
Monoclonal Gammopathy of Renal Significance (MGRS)

MGRS
• MGRS refers to kidney disease caused by nephrotoxic monoclonal immunoglobulins
light-chain ratio Diagnostic ... tubulopathy) - Complement ... formation causing vasculitis ... function and prevent progression ... #Significance #Diagnosis