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diagnosis differential nephrology glomerulonephritis rheumatology vasculitis glomerular hematology nephrotic renal testing workup anemia champs clinicopathology cryoglobulinemia cryoglobulins disease gammopathy hypokalemia
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
Causes of Hypocomplementemia ... @AnnKumfer #Hypocomplementemia ... #Low #Complement
Membranoproliferative Glomerulonephritis (MPGN) AKA: Mesangiocapillary GN • Active Urine Sediment (dysmorphic RBC, RBC casts, +/- proteinuria)
dysmorphic RBC, RBC casts ... staining (lg + complement ... rheumatoid arthritis, monoclonal ... MGPN • Complement ... immune deposits on EM
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
pathophysiologic causes ... staining): • Low ... Complement: Post-strep ... Idiopathic • Normal Complement ... differential #diagnosis #algorithm
Hypokalemia Differential Diagnosis Algorithm Low intake • poor oral intake Renal loss • Medication • Hypomagnesemia •
Differential Diagnosis Algorithm ... Low intake ... Differential #Diagnosis #Algorithm ... #Causes #Classification
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... Cryoglobulins Cause ... factor level • Low ... serum C4 complement ... diagnosis #types #classification
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Low Mean Corpuscular Volume (<80
Causes of Anemia ... Differential Diagnosis Algorithm ... Low Mean Corpuscular ... #Anemia #MCV #Classification ... #Causes #Hematology
Recommended initial testing for patients being evaluated for glomerular disease 24-hour urine collection - Quantify proteinuria.
in monitoring low-level ... chains - Screen for monoclonal ... for detection of monoclonal ... or alternative complement ... infections are common causes
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
tract, and often causes ... Urticaria and hypocomplementemia ... against MPO • Complement ... (Low levels mixed ... #rheumatology #classification
Recommended initial testing for patients being evaluated for glomerular disease 1) 24-hour urine collection - Quantify proteinuria.
in monitoring low-level ... or alternative complement ... chains - Screen for monoclonal ... for detection of monoclonal ... infections are common causes
Monoclonal Gammopathy of Renal Significance (MGRS) MGRS • MGRS refers to kidney disease caused by nephrotoxic monoclonal immunoglobulins
kidney disease caused ... Clinical Clues: ... guide subtype classification ... Damages Kidneys • Low ... tubulopathy) - Complement
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