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diagnosis treatment rheumatology differential neurology syndrome hematology lupus summary vasculitis druginduced sle symptoms barre erythematosus guillain hemophagocytic hlh lymphohistiocytosis signs
Pathophysiology of Hypocomplementemic Urticarial Vasculitis C1q/anti-C1q antibiody -> Immune Complex Formation - Complement Pathway Activation (C3a and C5a)
Pathophysiology ... of Hypocomplementemic ... Complex Formation - Complement ... TerrierBen #Hypocomplementemic ... Vasculitis #HUV #Pathophysiology
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
Causes of Hypocomplementemia ... @AnnKumfer #Hypocomplementemia ... #Low #Complement
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
three primary pathophysiologic ... causes differentiated ... staining): • Low Complement ... Idiopathic • Normal Complement
Drug-Induced Edema Drug-induced edema is caused by many drugs & can coincide with or worsen pre-existing peripheral
Drug-induced edema is caused ... Activation of the complement ... Edema #Medication #Causes ... #Pharmacology #Pathophysiology
Alcohol Withdrawal Summary Pathophysiology, Symptoms, Cause, Course, Management #Diagnosis #Management #Pathophysiology #Alcohol #Withdrawal #Symptoms
Withdrawal Summary Pathophysiology ... , Symptoms, Cause ... , Course, Management ... #Diagnosis #Management ... #Pathophysiology
Cyanide Toxicity Treatment: 1) Hydroxocobalamin + Cyanide = Cyanocobalamin (nontoxic) or 2) Amyl nitrite
Amyl nitrite - causes ... Toxicity #Toxicology #Pathophysiology ... #Management #Treatment
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Diagnosis and Management ... Positive in 60-80% of cases ... 80% - Low complement ... Usual therapeutic management ... Erythematosus #Diagnosis #Management
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
tract, and often causes ... often involved • Hypocomplementemic ... Urticaria and hypocomplementemia ... against MPO • Complement
Gonorrhea: Pathophysiology - Neonatal Transmission -> Direct contact of patient mucosa with mother's infected mucosa while
Gonorrhea: Pathophysiology ... antibodies and causes ... activation of complement ... #Gonorrhea #Pathophysiology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
90% - Low complement ... Discontinuation of causal ... 80% - Low complement ... Usual therapeutic management ... rheumatology #diagnosis #management
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