320 results
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
progressing GN • New pulmonary ... tract, and often causes ... often involved • Hypocomplementemic ... Urticaria and hypocomplementemia ... against MPO • Complement
Causes of Hypocomplementemia - CHAMPS Mnemonic
C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis
H - Heavy Chain deposition
Causes of Hypocomplementemia ... @AnnKumfer #Hypocomplementemia ... #Low #Complement
Pathophysiology of Hypocomplementemic Urticarial Vasculitis

C1q/anti-C1q antibiody ->
Immune Complex Formation - Complement Pathway Activation (C3a and C5a)
Pathophysiology of Hypocomplementemic ... Complex Formation - Complement ... TerrierBen #Hypocomplementemic
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
pathophysiologic causes ... staining): • Low Complement ... Idiopathic • Normal Complement ... With associated pulmonary
Causes of Hemolytic Anemia - Differential Diagnosis
Inherited
 • Membrane
 • Internal
    - Hemoglobin
Causes of Hemolytic ... Antibody/DAT+ - Complement ... Differential #Diagnosis #Causes
Membranoproliferative Glomerulonephritis (MPGN) AKA: Mesangiocapillary GN
 • Active Urine Sediment (dysmorphic RBC, RBC casts, +/- proteinuria)
dysmorphic RBC, RBC casts ... staining (lg + complement ... MGPN • Complement ... of alternative complement ... MPGN without complement
Pulmonary Renal Syndromes and Mimics - Differential Diagnosis Framework
Diffuse alveolar hemorrhage + rapidly progressive glomerulonephritis
90%:
 -
Pulmonary Renal ... anti-GBM) 10%: - Low Complement ... Vasculitis - Normal Complement ... Kumfer @AnnKumfer #Pulmonary
Causes of Pulmonary Fibrosis

#Pulmonary #Fibrosis #Causes #Differential #Diagnosis
Causes of Pulmonary ... Fibrosis #Pulmonary ... #Fibrosis #Causes
Hypoxemic Respiratory Failure - Differential Diagnosis Framework
DECREASED INSPIRED OXYGEN
 • Low PATM Can decrease first part
gas equation • Causes ... lung diseases, pulmonary ... asthma, COPD, pulmonary ... shunting (eg, pulmonary ... Differential #Diagnosis #pulmonary
Causes of Cough and Hemoptysis
Acute Inflammation 
 - Laryngitis 
 - Tracheobronchitis 
 - Mycoplasma and
Causes of Cough ... Bronchiectasis - Pulmonary ... Mitral Stenosis - Pulmonary ... , Chemicals, Gases ... #Differential #Causes