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diagnosis differential anemia rheumatology agglutinin autoimmune causes comparison criteria disease erythematosus eularacr extravascular hemolysis intravascular lupus management monoclonal oncology paraproteinemias
Warm vs Cold Autoimmune Hemolytic Anemia Warm Autoimmune Hemolytic Anemia: • Mechanism: IgG and Complement-mediated • Etiology:
• Mechanism: IgG ... and Complement-mediated ... Coombs positive for IgG ... Mechanism: IgM and Complement-mediated ... #Anemia #hematology
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Differential Diagnosis Algorithm ... Warm AIHA • Cold ... perfringens - Complement-Mediated ... • Cold AIHA ... #Causes #Hematology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Cryoglobulins (Vasculitic ... Diagnosis: • hemolytic ... Donath-Landsteiner (IgG ... temperatures by fixing complement ... #anemia #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Differential Diagnosis Algorithm ... Agglutination - Cold ... cardiac valve, vasculitis ... Differential #Diagnosis #Algorithm ... #workup #hematology
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus Clinical Domains: • Constitutional domain: Fever • Cutaneous domain: Non-scarring
EULAR/ACR Classification ... Thrombocytopenia, Autoimmune hemolysis ... Anticardiolipin IgG ... or anti-ß2GPI IgG ... anticoagulant • Complement
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
often involved • Hypocomplementemic ... Urticaria and hypocomplementemia ... against MPO • Complement ... differential #diagnosis #rheumatology ... #classification
IGG-4 RELATED DISEASE WHAT? • A chronic, immune-mediated fibroinflammatory disease with tumefactive infiltration of IgG4+ plasma cells
IGG-4 RELATED DISEASE ... aortitis, mimics vasculitis ... - ↑ IgE, ↓ complement ... • Classification ... #Management #Rheumatology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Autoimmunity: • -MM/WM: Vasculitis ... • Coombs (-) hemolytic ... anemia due to cold ... IgG • Lupus anticoagulant ... Paraproteinemias #Hematology
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