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diagnosis rheumatology types allergy management pathophysiology reactions table vasculitis allergic causes comparison cryoglobulinemia cryoglobulins definitions differential druginduced edema erythematosus gammopathy
Pathophysiology of Hypocomplementemic Urticarial Vasculitis C1q/anti-C1q antibiody -> Immune Complex Formation - Complement Pathway Activation (C3a and C5a)
Pathophysiology of Hypocomplementemic ... Complex Formation - Complement ... Pathway Activation ... Chemokines, Cytokines, Mast ... TerrierBen #Hypocomplementemic
Hypersensitivity Types and Their Mechanisms Type I - lgE - Soluble antigen - Allergen-specific lgE antibodies bind
Hypersensitivity ... antibodies bind to mast ... to complement activation ... Complement activation ... #Types #Classification
Summary table of types of hypersensitivity reactions. Type 1 - Mediators: lgE - Antigen Form: Soluble
table of types of hypersensitivity ... Allergen-specific lgE causes mast-cell ... cell antigens, leading ... to complement activation ... allergy #table #classification
Drug-Induced Edema Drug-induced edema is caused by many drugs & can coincide with or worsen pre-existing peripheral
- Bradykinin (has ... blood vessels, leading ... Histamine release from mast ... oxide release - Activation ... of the complement
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Macrophage Activation ... IL-1 and IL-6, leading ... nervous system (CNS) dysfunction ... • Drug-induced hypersensitivity ... #Macrophage #Activation
Hypersensitivity: Definitions • Type I - Production of lgE Abs that bind to harmless allergens and
Hypersensitivity ... allergens and activate mast ... because T-Cell activation ... #Hypersensitivity ... Reactions #Types #Classification
SEPSIS AND SEPTIC SHOCK DEFINITION AND PATHOPHYSIOLOGY • Sepsis: Life-threatening organ dysfunction due to a dysregulated host
Life-threatening organ dysfunction ... cellular/metabolic dysfunction ... Infection + Organ dysfunction ... NETs), cytokines, complement ... activation
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
immune system, leading ... • Low serum C4 complement ... vasculitis • Hypersensitivity ... diagnosis #types #classification
IGG-4 RELATED DISEASE WHAT? • A chronic, immune-mediated fibroinflammatory disease with tumefactive infiltration of IgG4+ plasma cells
- Organ dysfunction ... progressive organ dysfunction ... radiologic evidence of mass ... - ↑ IgE, ↓ complement ... • Classification
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
anti-Smith Ab, low complements ... Skin Disease Classification ... mild cognitive dysfunction ... RNP antibodies, Complement ... Chronic B-cell activation
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