12 results
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
Rapidly Progressive ... three primary pathophysiologic ... staining): • Low Complement ... #differential #diagnosis ... #algorithm #rheumatology
IGG-4 RELATED DISEASE

WHAT?
 • A chronic, immune-mediated fibroinflammatory disease with tumefactive infiltration of IgG4+ plasma cells
dysfunction PATHOPHYSIOLOGY ... inflammation -> progressive ... - ↑ IgE, ↓ complement ... • Classification ... -4 #IGG4 #Diagnosis
Hypersensitivity Types and Their Mechanisms
Type I - lgE - Soluble antigen
 - Allergen-specific lgE antibodies bind
antigen, leading to complement ... Complement activation ... Hypersensitivity #Types #Classification ... #Pathophysiology ... #Allergy #Diagnosis
Classification of COVID-19 Disease States and Potential Therapeutic Targets

Viral Response Phase -> Host Inflammatory Response Phase
Stage
Classification of ... inhibitors #COVID19 #Progression ... #Classification ... #Diagnosis #Pathophysiology
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus
Clinical Domains:
 • Constitutional domain: Fever
 • Cutaneous domain: Non-scarring
EULAR/ACR Classification ... Anticardiolipin IgG ... or anti-ß2GPI IgG ... anticoagulant • Complement ... Erythematosus #diagnosis
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm
Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
- Differential Diagnosis ... Algorithm Hodgkin ... system (node) with progression ... Lymphoproliferative #Disorders #Classification ... #pathophysiology
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
- Differential Diagnosis ... proteinuria, rapidly progressing ... Urticaria and hypocomplementemia ... against MPO • Complement ... #rheumatology #classification
Guillain-Barre Syndrome - Summary

Acute AIDP that presents with rapidly progressive flaccid weakness

Epidemiology:
 • 1-2 cases/100,000 per
presents with rapidly progressive ... Guillain-Barre Pathophysiology ... Guillain-Barre Diagnosis ... equina • GQ1b IgG ... Barre #Syndrome #diagnosis
Transverse Myelitis Overview

Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
monophasic Pathophysiology ... bouts of HTN Diagnostic ... index • Progression ... Transverse Myelitis Diagnosis ... Transverse #Myelitis #diagnosis
Hepatorenal Syndrome (HRS)

Definition:
• Functional, potentially reversible kidney impairment.
• Occurs in advanced liver disease: cirrhosis, severe alcoholic
Pathophysiology: ... Diagnosis (Clinical ... Classification: ... Type 1): • Rapid progression ... Diagnostic Support