14 results
diagnosis rheumatology lupus erythematosus allergy criteria differential management table types vasculitis c5c9deficiency cascade comparison cryoglobulinemia cryoglobulins disorders druginduced eularacr hematology
Inflammatory Cascade: Pathogenesis and Clinical Findings Continued Innate Immunity • Phagocytosis: (main mechanism) neutrophils and macrophages engulf
dead tissue • Complement ... System: opsonize ... activation of complement ... #Inflammation #pathophysiology ... #immunology
Systemic Lupus Erythematosus (SLE): Pathogenesis • Genetic factors (Mutations in HLA- DR2/HLA-DR3 genes, complement genes, cytokine
(SLE): Pathogenesis ... HLA-DR3 genes, complement ... self-antigens, activating complement ... Erythematosus #SLE ... #Pathophysiology
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... (SLE) - Diagnosis ... Cytopenia: Common • Immunologic ... 80% - Low complement ... #lupus #Systemic
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus Clinical Domains: • Constitutional domain: Fever • Cutaneous domain: Non-scarring
EULAR/ACR Classification ... Criteria for Systemic ... lupus nephritis Immunologic ... anticoagulant • Complement ... #Criteria #SLE
Type III Hypersensitivity: Pathogenesis and clinical findings Definition: Small antigen-antibody complexes (produced from normal immune response to
the cause: • Systemic ... Erythematosus (SLE ... HypersensitivityReaction #Allergy #Immunology ... #pathophysiology
SLICC SLE Diagnostic Criteria - Systemic Lupus Erythematosus Clinical and Immunologic Criteria CLINICAL CRITERIA - ACUTE CUTANEOUS LUPUS
SLICC SLE Diagnostic ... Criteria - Systemic ... <100,000/MM3) IMMUNOLOGIC ... anticoagulant - Low complement ... #Rheumatology #SLE
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
drug-dependent) • Immunologic ... 90% - Low complement ... months to years) Systemic ... Cytopenia: Common • Immunologic ... 80% - Low complement
C5-C9 Deficiency - Pathogenesis and Clinical Findings Note: • Risk of invasive meningococcal disease is 1000-10000x higher
is rare Normal complement ... response: The complement ... susceptibility to systemic ... #pathophysiology ... #immunology
Humoral Immunity - Pathogenesis and Clinical Findings Antigens (Ag) are produced from pathogens (bacteria, viruses, fungi, parasites)
activation • Complement ... classical pathway (see ... Complement Activation ... Humoral #Immunity #pathophysiology ... #immunology
Hypersensitivity Types and Their Mechanisms Type I - lgE - Soluble antigen - Allergen-specific lgE antibodies bind
- Local and systemic ... Complement activation ... arthritis, and systemic ... Hypersensitivity #Types #Classification ... #Pathophysiology
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