17 results
Lupus Nephritis Primer
Class I - Minimal Mesangial
Class II - Mesangial Proliferative
Class Ill - Focal Proliferative
Class IV
Lupus Nephritis ... IV - Diffuse Proliferative ... #Nephritis #SLE ... #differential # ... diagnosis #management
Causes of Hypocomplementemia - CHAMPS Mnemonic
C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis
H - Heavy Chain deposition
Causes of Hypocomplementemia ... S - Systemic Lupus ... @AnnKumfer #Hypocomplementemia ... #Low #Complement ... Mnemonic #diagnosis #differential
Management of Lupus Nephritis
Lupus nephritis (LN) in 10 to 40% of SLE
Hallmark = proteinuria 20.5 g/g
Management of Lupus ... Nephritis Lupus ... IV - Diffuse LN ... glomeruli) Diffuse ... #Nephritis #Management
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
pathophysiologic causes ... Post-strep GN, Lupus ... Nephritis, Cryoglobulinemia ... Glomerulonephritis #Vasculitis #differential ... #diagnosis #algorithm
Algorithm for the Treatment of Membranous Lupus Nephritis
Sub-nephrotic-range proteinuria (<3.5g/d, normal serum albumin) and Preserved kidney
Algorithm for the ... of Membranous Lupus ... #Membranous #Lupus ... #Nephritis #Algorithm ... #Treatment #management
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
anti-Smith Ab, low complements ... permanent alopecia Differential ... pneumonitis • Diffuse ... enteropathy, and diffuse ... RNP antibodies, Complement
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary
 • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... Diagnosis and Management ... nephritis, NPSLE ... Positive in 60-80% of cases ... 80% - Low complement
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm
Reactive:
 - Systemic Inflammatory
     •
Causes of Diffuse ... Diagnosis Algorithm ... • Systemic Lupus ... Hodgkin's Lymphoma #Diffuse ... #Diagnosis #Algorithm
Causes of Hematuria - Differential Diagnosis Algorithm
Red blood cells on urine microscopy. Must exclude false positives
- Differential ... Diagnosis Algorithm ... IgA, post-strep, lupus ... and >3.5g/day (nephrotic ... #Diagnosis #Algorithm
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
90% - Low complement ... nephritis, NPSLE ... 80% - Low complement ... Usual therapeutic management ... rheumatology #diagnosis #management