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differential rheumatology causes hematology erythematosus pathophysiology pulmonary sle types vasculitis allergy champs criteria cryoglobulinemia cryoglobulins disorders eularacr high hyperkalemia hypersensitivity
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
Causes of Hypocomplementemia ... glomerulonephritis (>90%) S - Systemic ... Lupus Erythematosus ... #Low #Complement ... CHAMPS #Mnemonic #diagnosis
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus Clinical Domains: • Constitutional domain: Fever • Cutaneous domain: Non-scarring
EULAR/ACR Classification ... Criteria for Systemic ... Thrombocytopenia, Autoimmune hemolysis ... anticoagulant • Complement ... #diagnosis #rheumatology
Causes of Hemoptysis - Differential Diagnosis Algorithm Massive Hemoptysis (>I00 mL in 24 hours) • Malignancy •
- Differential Diagnosis ... Algorithm Massive ... • Bronchitis Diffuse ... Vasculitis • Lupus ... #Algorithm #Causes
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm Reactive: - Systemic Inflammatory •
Causes of Diffuse ... - Differential Diagnosis ... Algorithm Reactive ... • Systemic ... Lupus Erythematosus
Pulmonary Renal Syndrome Definition: Diffuse alveolar hemorrhage + Glomerulonephritis Presentation (Pulmonary and renal manifestations can occur weeks apart):
Definition: Diffuse ... Fever, Hematuria, Hemoptysis ... Differential Diagnosis ... Immune Complex: Systemic ... lupus erythematosus
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
Urticaria and hypocomplementemia ... inflammation Others: • Lupus ... lupus erythematosus ... against MPO • Complement ... #rheumatology #classification
Hypersensitivity Types and Their Mechanisms Type I - lgE - Soluble antigen - Allergen-specific lgE antibodies bind
- Local and systemic ... Complement activation ... lupus erythematosus ... Hypersensitivity #Types #Classification ... Pathophysiology #Allergy #Diagnosis
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... anti-Smith Ab, low complements ... Skin Disease Classification ... Differential Diagnosis ... pneumonitis • Diffuse
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
- Differential Diagnosis ... Algorithm Hodgkin ... with lymphatic system ... lymphadenopathy more diffuse ... Lymphoproliferative #Disorders #Classification
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
activate the immune system ... Labs/Diagnosis: ... • Low serum C4 complement ... lupus erythematosus ... #types #classification
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