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differential rheumatology classification management sle vasculitis alopecia dermatology druginduced erythematosus hairloss hematology systemic champs cryoglobulinemia cryoglobulins dil focal glomerulonephritis hemoptysis
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
Causes of Hypocomplementemia ... S - Systemic Lupus ... @AnnKumfer #Hypocomplementemia ... #Low #Complement ... CHAMPS #Mnemonic #diagnosis
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
pathophysiologic causes ... staining): • Low ... GN, Lupus Nephritis ... #differential #diagnosis ... #algorithm #rheumatology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
in >90% - Low ... complement - Rare ... complement - 50 ... #sle #comparison ... #rheumatology #diagnosis
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm Reactive: - Systemic Inflammatory •
Causes of Diffuse ... - Differential Diagnosis ... Algorithm Reactive ... • Systemic Lupus ... #Algorithm #Causes
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
(SLE) - Diagnosis ... Positive in 60-80% of cases ... 60-80% - Low ... complement - 50 ... Erythematosus #Diagnosis
Causes of Hemoptysis - Differential Diagnosis Algorithm Massive Hemoptysis (>I00 mL in 24 hours) • Malignancy •
Causes of Hemoptysis ... Algorithm Massive ... • Bronchitis Diffuse ... Vasculitis • Lupus ... #Algorithm #Causes
Hair Loss (Alopecia) - General (Diffuse and Focal) Differential Diagnosis Algorithm DIFFUSE Scarring - Irreversible-biopsy required • Lupus
) Differential Diagnosis ... Algorithm DIFFUSE ... • Discoid lupus ... #Differential #Diagnosis ... #Algorithm #causes
Myositis and Myopathies Polymyositis • Progressive, symmetric muscle weakness • Elevated CK, +Anti-Jo, +Anti-Mi2 Dermatomyositis
Body Myositis • Slow ... Myopathy • Diffuse ... uncommon 5-15% of lupus ... #differential #diagnosis ... #comparison #rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
anti-Smith Ab, low ... complements and ... Differential Diagnosis ... pneumonitis • Diffuse ... , lymphopenia, low
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
tract, and often causes ... inflammation Others: • Lupus ... such as systemic lupus ... against MPO • Complement ... (Low levels mixed
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