14 results
Causes of Hypocomplementemia - CHAMPS Mnemonic
C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis
H - Heavy Chain deposition
Causes of Hypocomplementemia ... S - Systemic Lupus ... @AnnKumfer #Hypocomplementemia ... #Low #Complement
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus
Clinical Domains:
 • Constitutional domain: Fever
 • Cutaneous domain: Non-scarring
EULAR/ACR Classification ... anticoagulant • Complement ... C3 or low C4, Low ... C3 and low C4 ... #EULARACR #Classification
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
staining): • Low ... Complement: Post-strep ... GN, Lupus Nephritis ... Idiopathic • Normal Complement ... differential #diagnosis #algorithm
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm
Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
Differential Diagnosis Algorithm ... lymphadenopathy more diffuse ... B-Cell ~90% • Low ... age range • High ... Lymphoproliferative #Disorders #Classification
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
anti-Smith Ab, low ... complements and ... a high erythrocyte ... Skin Disease Classification ... , lymphopenia, low
Complement Deficiency Testing Algorithm
 • Normal CH50 and AH50 AND High suspicion for complement deficiency
 •
Complement Deficiency ... Testing Algorithm ... CH50 and AH50 AND High ... deficiency • Low ... Deficiency #Testing #Algorithm
A priority in this project was to appropriately stratify participants into a low, medium, or high-intensity
participants into a low ... , medium, or high-intensity ... The classification ... CDC, entitled “Algorithm ... The algorithm is
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
inflammation Others: • Lupus ... such as systemic lupus ... against MPO • Complement ... (Low levels mixed ... #rheumatology #classification
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Low Mean Corpuscular Volume (<80
Differential Diagnosis Algorithm ... Low Mean Corpuscular ... Chronic Infection) High ... #Anemia #MCV #Classification ... Differential #Diagnosis #Algorithm
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
factor level • Low ... serum C4 complement ... (e.g. systemic lupus ... diagnosis #types #classification