14 results
Causes of Hypocomplementemia - CHAMPS Mnemonic
C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis
H - Heavy Chain deposition
Causes of Hypocomplementemia ... glomerulonephritis (>90%) S - Systemic ... Lupus Erythematosus ... @AnnKumfer #Hypocomplementemia ... #Low #Complement
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary
 • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... , oral ulcers, Lupus ... Positive in 60-80% of cases ... 80% - Low complement ... #lupus #Systemic
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus
Clinical Domains:
 • Constitutional domain: Fever
 • Cutaneous domain: Non-scarring
EULAR/ACR Classification ... Criteria for Systemic ... anticoagulant • Complement ... #Criteria #SLE ... #Systemic #Lupus
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
vs SLE Drug Induced ... 90% - Low complement ... Discontinuation of causal ... months to years) Systemic ... 80% - Low complement
Type III Hypersensitivity: Pathogenesis and clinical findings
Definition: Small antigen-antibody complexes (produced from normal immune response to
Type III Hypersensitivity ... self-antigens are the cause ... : • Systemic Lupus ... Erythematosus (SLE ... antigens are the cause
Hypersensitivity Types and Their Mechanisms
Type I - lgE - Soluble antigen
 - Allergen-specific lgE antibodies bind
Hypersensitivity ... - Local and systemic ... Complement activation ... lupus erythematosus ... #Types #Classification
Summary table of types of hypersensitivity reactions. 
Type 1
 - Mediators: lgE
 - Antigen Form: Soluble
table of types of hypersensitivity ... Allergen-specific lgE causes ... glomerulonephritis, Systemic ... lupus erythematosus ... allergy #table #classification
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... anti-Smith Ab, low complements ... Skin Disease Classification ... RNP antibodies, Complement ... #Systemic #Lupus
Causes of Interstitial Lung Disease - Differential Diagnosis Algorithm
Idiopathic Interstitial Pneumonia
 • (UIP) Usual Interstitial Pneumonia
Causes of Interstitial ... Differential Diagnosis Algorithm ... Rheumatoid Arthritis, Systemic ... Lupus and Scleroderma ... Diseases #ILD #Causes
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... • Low serum C4 complement ... vasculitis • Hypersensitivity ... lupus erythematosus ... diagnosis #types #classification