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diagnosis rheumatology causes hematology anemia classification hemolytic workup agglutinin champs clinicopathology cold cryoglobulinemia cryoglobulins disease erythematosus fetal gi glomerulonephritis headache
Pathophysiology of Hypocomplementemic Urticarial Vasculitis C1q/anti-C1q antibiody -> Immune Complex Formation - Complement Pathway Activation (C3a and C5a)
Pathophysiology of Hypocomplementemic ... Urticarial Vasculitis ... Complex Formation - Complement ... Formation -> Vasculitis ... TerrierBen #Hypocomplementemic
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
Causes of Hypocomplementemia ... @AnnKumfer #Hypocomplementemia ... #Low #Complement ... Mnemonic #diagnosis #differential
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
often involved • Hypocomplementemic ... Urticaria and hypocomplementemia ... against MPO • Complement ... (Low levels mixed ... , and SLE) • Urinalysis
Pulmonary Renal Syndromes and Mimics - Differential Diagnosis Framework Diffuse alveolar hemorrhage + rapidly progressive glomerulonephritis 90%: -
Syndromes and Mimics - Differential ... anti-GBM) 10%: - Low ... Complement Levels ... : SLE, Cryoglobulinemic ... - Normal Complement
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
staining): • Low ... Complement: Post-strep ... Glomerulonephritis #Vasculitis ... #differential # ... diagnosis #algorithm
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Vasculitis - Differential ... Differential Diagnosis ... diseases, such as SLE ... Elevated AST ALT • Hypocomplementemia ... ) • Hypocomplementemic
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Thrombocytopenia - Differential ... Diagnosis Algorithm ... Autoimmune • ITP • SLE ... HUS • DIC • Vasculitis ... #Diagnosis #Algorithm
Causes of Polyneuropathy - Differential Diagnosis Algorithm • Metabolic: DM, Hypothyroidism, CKD, Cirrhosis, Nutritional deficiency •
Polyneuropathy - Differential ... Diagnosis Algorithm ... Paraneoplastic, CTD (SLE ... RA, Sjogren’s), Vasculitis ... #Diagnosis #Algorithm
Causes of Headache - Differential Diagnosis Algorithm Primary: Tension, Migraine, Cluster Extracranial: Medications, Sinusitis, TMJ disorder, Cervicogenic, Glaucoma,
of Headache - Differential ... Diagnosis Algorithm ... Aneurysm, Hemorrhage, Vasculitis ... Pseudotumor Cerebri, Low ... Diagnosis #Causes #algorithm
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
diseases: - 10% SLE ... factor level • Low ... serum C4 complement ... • Vasculitis ... erythematosus (SLE
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