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diagnosis rheumatology causes hematology lupus erythematosus hyperkalemia renal systemic vasculitis acidosis agglutinin anemia c4 cardiology champs clinicopathology cold criteria cryoglobulinemia
Effect of Selected Diseases on Complement Levels - C3, C4 • SLE C3 ↓ C4 ↓↓
Selected Diseases on Complement ... • SLE C3 ↓ C4 ... ↓↓ • MCGN type ... ThePeanutKidney #Complement ... #differential #
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
Causes of Hypocomplementemia ... Cryoglobulinemia (85%), C3 ... 1 (50%-80%), type ... #Low #Complement ... Mnemonic #diagnosis #differential
Lupus Nephritis Classification Algorithm #Lupus #Nephritis #Classification #Algorithm #diagnosis #differential #types #rheumatology #nephrology #renal
Lupus Nephritis Classification ... Algorithm #Lupus ... #Algorithm #diagnosis ... #differential # ... types #rheumatology
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus Clinical Domains: • Constitutional domain: Fever • Cutaneous domain: Non-scarring
EULAR/ACR Classification ... anticoagulant • Complement ... proteins domain: Low C3 ... or low C4, Low C3 ... #Criteria #SLE
Subtypes of Serum Proteins Pre-albumin (Transthyretin) Albumin Globulins • Alpha-1: Alpha-1 antitrypsin, Serum amyloid A, Ceruloplasmin, Corticosteroid-binding globulin (Transcortin),
Angiotensinogen • Beta: C3 ... Proteins #Subtypes #algorithm ... #classification ... #Types #hematology
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
diseases: - 10% SLE ... Types: • Type ... • Low serum C4 complement ... erythematosus (SLE ... #classification
Humoral Immunity - Pathogenesis and Clinical Findings Antigens (Ag) are produced from pathogens (bacteria, viruses, fungi, parasites)
activation • Complement ... Ags tagged with C3 ... complement fragment ... classical pathway (see ... proliferate and differentiate
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
anti-Smith Ab, low complements ... Skin Disease Classification ... permanent alopecia Differential ... Kikuchi disease • Type-I ... levels (C3 and
The Diagnostic Approach to Hyperkalemia Drugs - Amiloride - Spironolactone - Triamterene - Trimethoprim - Pentamidine -
obstruction _ pHA type ... I, type II - ... transplant - SLE ... #Hyperkalemia #Algorithm ... #diagnosis #differential
Types of Melanoma Superficial Spreading • Most common form • Often develops in previously benign mole •
Types of Melanoma ... • Most common type ... eye you cannot see ... #differential # ... diagnosis #classification
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