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diagnosis differential rheumatology nephrology classification renal treatment aki glomerulonephritis management pulmonary workup acr2021 acute causes disease granulomatosis guidelines injury kidney
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
- Skin, glomeruli ... often involved • Hypocomplementemic ... Urticaria and hypocomplementemia ... : - Kidneys: glomerular ... against MPO • Complement
ANCA-Associated Vasculitis A group of necrotizing, small-vessel vasculitis without immune complex deposition. Complement levels are normal due
Vasculitis A group ... , small-vessel vasculitis ... Complement levels ... vasculitis - MPO ... @AnnKumfer #ANCA
Pathophysiology of Hypocomplementemic Urticarial Vasculitis C1q/anti-C1q antibiody -> Immune Complex Formation - Complement Pathway Activation (C3a and C5a)
Pathophysiology of Hypocomplementemic ... Urticarial Vasculitis ... Complex Formation - Complement ... Formation -> Vasculitis ... TerrierBen #Hypocomplementemic
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
staining): • Low Complement ... Idiopathic • Normal Complement ... (C-ANCA): GPA > ... Glomerulonephritis #Vasculitis ... differential #diagnosis #algorithm
A System for Vasculitides #Diagnosis #IM #Rheum #Vasculitis #Small #Medium #Large #Vessel #Size #Classification #ANCA #Differential
A System for Vasculitides ... Diagnosis #IM #Rheum #Vasculitis ... Classification #ANCA ... #Differential #Algorithm
Pulmonary Renal Syndrome Definition: Diffuse alveolar hemorrhage + Glomerulonephritis Presentation (Pulmonary and renal manifestations can occur weeks apart):
vasculitis (Eosinophilic ... vasculitis (IgA-associated ... vasculitis, Behcet ... sclerosis • Anti-Glomerular ... testing: anti-ANCA
Pulmonary Renal Syndromes and Mimics - Differential Diagnosis Framework Diffuse alveolar hemorrhage + rapidly progressive glomerulonephritis 90%: -
glomerulonephritis 90%: - ANCA ... Associated Vasculitis ... Double Positive (ANCA ... anti-GBM) 10%: - Low Complement ... - Normal Complement
Approach to managing Glomerulonephritis (GN) in children. ANCA, antineutrophil cytoplasmic antibodies; c-ANCA, cytoplasmic antineutrophil cytoplasmic antibodies;
ANCA, antineutrophil ... antibodies; c-ANCA ... antibodies; GBM, glomerular ... hypertension; p-ANCA ... Glomerulonephritis #Algorithm
Vasculitis - Break down based on vessel size Distribution of vessel involvement by large vessel vasculitis,
Vasculitis - Break ... by large vessel vasculitis ... medium vessel vasculitis ... Anti-GBM = anti–glomerular ... basement membrane; ANCA
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
• Kidneys: Non-glomerular ... : ANCA Associated ... Pauci Immune (ANCA ... Elevated AST ALT • Hypocomplementemia ... ) • Hypocomplementemic
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