33 results
Pathophysiology of Hypocomplementemic Urticarial Vasculitis

C1q/anti-C1q antibiody ->
Immune Complex Formation - Complement Pathway Activation (C3a and C5a)
Pathophysiology of Hypocomplementemic ... Urticarial Vasculitis ... Complex Formation - Complement ... Formation -> Vasculitis ... TerrierBen #Hypocomplementemic
Kidney Biopsy - Diagnosis Algorithms
1) Normal Glomerulus by LM
2) Glomerular Crescents
3) Double Contours of GBM
4) Endocapillary
Biopsy - Diagnosis Algorithms ... 1) Normal Glomerulus ... by LM 2) Glomerular ... renal #Diagnosis #Algorithm ... #nephrology #pathology
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
- Skin, glomeruli ... often involved • Hypocomplementemic ... Urticaria and hypocomplementemia ... : - Kidneys: glomerular ... against MPO • Complement
Membranoproliferative Glomerulonephritis (MPGN) AKA: Mesangiocapillary GN
 • Active Urine Sediment (dysmorphic RBC, RBC casts, +/- proteinuria)
formation along glomerular ... staining (lg + complement ... MGPN • Complement ... of alternative complement ... Glomerulonephritis #MPGN #nephrology
Causes of Hematuria - Glomerular vs Non-glomerular

== Glomerular ==
- Glomerulonephritis 
- Thin basement membrane disease 

==
of Hematuria - Glomerular ... vs Non-glomerular ... == Glomerular ... #Algorithm #Diagnosis ... #Differential #Urology
Drug Induced Kidney Injury
 • Pre-Renal: NSAIDS, CNI, ACEI/ARB, IL-2 therapy, Diuretics CAR-T therapy
 • Osmotic
Vitamin C • Glomerular ... : Drug induced vasculitis ... differential #diagnosis #algorithm ... #nephrology #Medications
Hematuria Workup and Diagnosis Algorithm
 • Confirm hematuria → Urinalysis >3 RBCs/HPF, exclude mimics, repeat testing
and Diagnosis Algorithm ... • Evidence of glomerular ... → Refer to Nephrology ... Hematuria #Diagnosis #Algorithm ... #Workup #urology
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
affects the skin, neurologic ... • Kidneys: Non-glomerular ... cognitive impairment, neurologic ... Elevated AST ALT • Hypocomplementemia ... ) • Hypocomplementemic
Recommended initial testing for patients being evaluated for glomerular disease 

24-hour urine collection - Quantify proteinuria.
evaluated for glomerular ... monitoring low-level glomerular ... or alternative complement ... for ANCA-related vasculitis ... nephrotic #nephritic #nephrology
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
staining): • Low Complement ... Idiopathic • Normal Complement ... Glomerulonephritis #Vasculitis ... differential #diagnosis #algorithm