13 results
diagnosis differential causes hematology disease workup glomerular glomerulonephritis hemolytic management nephrology rheumatology systemic abscess agglutinin chestpain dermatology erythematosus extravascular hemolysis
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Cryoglobulins (Vasculitic ... • Symptoms of anemia ... • hemolytic anemia ... Positive Coombs testing ... temperatures by fixing complement
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Differential Diagnosis Algorithm ... Warm AIHA • Cold ... perfringens - Complement-Mediated ... • Cold AIHA ... immune-complex hemolytic anemia
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... Differential Diagnosis Algorithm ... Agglutination - Cold ... cardiac valve, vasculitis ... workup #hematology #testing
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
staining): • Low Complement ... Post-strep GN, Lupus Nephritis ... Idiopathic • Normal Complement ... Glomerulonephritis #Vasculitis ... differential #diagnosis #algorithm
Vascular Joint Pain - Differential Diagnosis Algorithm - Constant Pain (Ischemia) - Acute Onset -
Differential Diagnosis Algorithm ... Claudication) - Cold ... Hyperemia Spasm • Vasculitis ... • Sickle Cell Anemia ... Air Embolism • Vasculitis
Nail Disorders secondary to Systemic Diseases Nail Fold Abnormality • SLE • Scleroderma • Dermatomyositis Koilonychia - Spoon-shaped
Diseases Nail Fold ... Iron deficiency anemia ... renal failure • Uremia ... discoloration) • Nephrotic ... Differential #Diagnosis #Algorithm
Recommended initial testing for patients being evaluated for glomerular disease 24-hour urine collection - Quantify proteinuria.
Recommended initial testing ... or alternative complement ... for ANCA-related vasculitis ... #glomerular #testing ... #nephritic #nephrology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
anti-Smith Ab, low complements ... ANCA-associated vasculitis ... • Mesenteric vasculitis ... lymphopenia, low PLT • Anemia ... RNP antibodies, Complement
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
Differential Diagnosis Algorithm ... hemolysis, deficiency anemia ... Rheumatologic, Vasculitides ... disease, Kawasaki, Nephrotic ... Differential #Diagnosis #Algorithm
Recommended initial testing for patients being evaluated for glomerular disease 1) 24-hour urine collection - Quantify proteinuria.
Recommended initial testing ... or alternative complement ... for ANCA-related vasculitis ... #nephrology #nephrotic ... #nephritis
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