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diagnosis differential rheumatology nephrology testing acute aki glomerular hematology injury kidney nephrotic renal anemia causes champs cryoglobulinemia cryoglobulins disease gammopathy
Pathophysiology of Hypocomplementemic Urticarial Vasculitis C1q/anti-C1q antibiody -> Immune Complex Formation - Complement Pathway Activation (C3a and C5a)
Pathophysiology of Hypocomplementemic ... Urticarial Vasculitis ... Complex Formation - Complement ... TerrierBen #Hypocomplementemic ... #HUV #Pathophysiology
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
Causes of Hypocomplementemia ... A - Atypical HUS ... Post/pauci immune glomerulonephritis ... @AnnKumfer #Hypocomplementemia ... #Low #Complement
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
often involved • Hypocomplementemic ... Urticaria and hypocomplementemia ... against MPO • Complement ... • HBV HCV • ... #rheumatology #classification
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
Rapidly Progressive Glomerulonephritis ... staining): • Low Complement ... Idiopathic • Normal Complement ... #Vasculitis #differential ... #diagnosis #algorithm
Pulmonary Renal Syndromes and Mimics - Differential Diagnosis Framework Diffuse alveolar hemorrhage + rapidly progressive glomerulonephritis 90%: -
rapidly progressive glomerulonephritis ... ANCA Associated Vasculitis ... anti-GBM) 10%: - Low Complement ... - Normal Complement ... , atypical HUS,
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Skin ulcers - Glomerulonephritis ... • Infections: HCV ... infection, HBV ... • Low serum C4 complement ... diagnosis #types #classification
Acute Kidney Injury - AKI Workup Algorithm and Differential Diagnosis Baseline Investigations: full blood count with differential,
Kidney Injury - AKI Workup ... Algorithm and Differential ... and signs • Glomerulonephritis ... / Vasculits: ANCA ... #Injury #AKI #Workup
Acute Kidney Injury - Classification Prerenal: • Dehydration • Heart failure (a.k.a. cardiorenal syndrome) • Liver failure
Kidney Injury - Classification ... - Small vessel vasculitis ... - TTP/HUS ... Post-infectious glomerulonephritis ... Kidney #Injury #Classification
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
HTN • Check: HBV ... , pauci-immune glomerulonephritis ... (Glomerulonephritis ... Elevated AST ALT • Hypocomplementemia ... ) • Hypocomplementemic
Recommended initial testing for patients being evaluated for glomerular disease 24-hour urine collection - Quantify proteinuria.
or alternative complement ... antibody, and HIV ... for ANCA-related vasculitis ... glomerular #testing #workup ... #diagnosis #glomerulonephritis
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