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diagnosis differential nephrology aki acute injury workup rheumatology classification disease glomerulonephritis hematuria kidneyinjury nephrotic renal urology acutekidneyinjury blood chloride chronic
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
tract, and often causes ... - Skin, glomeruli ... : glomerular ischemia ... Kidneys -> glomerulonephritis ... against MPO • Complement
Causes of Hematuria - Glomerular vs Non-glomerular == Glomerular == - Glomerulonephritis - Thin basement membrane disease ==
Causes of Hematuria ... == Kidney - ... - Polycystic kidney ... #Algorithm #Diagnosis ... Nonglomerular #Causes
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
pathophysiologic causes ... staining): • Low Complement ... • Limited to Kidney ... Glomerulonephritis #Vasculitis ... differential #diagnosis #algorithm
Causes of Acute Kidney Injury - Differential Diagnosis Framework Pre-Renal Post-Renal Intrinsic Renal: • Tubules (ATN) • Glomerular:
Causes of Acute ... Kidney Injury - ... Tubules (ATN) • Glomerular ... #KidneyInjury #Causes ... Differential #Diagnosis #Algorithm
Acute Kidney Injury - Differential Diagnosis Framework PRERENAL: - Intrarenal vasoconstriction-hemodynamically mediated - Systemic vasodilation - Volume
Acute Kidney Injury ... INTRINSIC: - Glomerular ... nephrotoxic drugs, treating ... underlying cause ... appropriate) #Acute #Kidney
Causes of Chronic Kidney Disease - Differential Diagnosis Algorithm Decreased kidney function (eGFR < 60 ml/min/1.73 m2)
Causes of Chronic ... Differential Diagnosis Algorithm ... Atherosclerosis Glomerular ... Differential #Diagnosis #Algorithm ... #Causes
Recommended initial testing for patients being evaluated for glomerular disease 24-hour urine collection - Quantify proteinuria.
Recommended initial testing ... or alternative complement ... infections are common causes ... for ANCA-related vasculitis ... #testing #workup
Acute Kidney Injury - Classification Prerenal: • Dehydration • Heart failure (a.k.a. cardiorenal syndrome) • Liver failure
Acute Kidney Injury ... - Small vessel vasculitis ... - TTP/HUS • Glomerular ... tubular necrosis (causes ... #AKI #Acute #Kidney
Causes of Proteinuria - Differential Diagnosis Algorithm Persistent Proteinuria >150mg/d protein present on repeat testing including overnight
Causes of Proteinuria ... Differential Diagnosis Algorithm ... present on repeat testing ... including overnight testing ... • Drugs Glomerular
Drug Induced Kidney Injury • Pre-Renal: NSAIDS, CNI, ACEI/ARB, IL-2 therapy, Diuretics CAR-T therapy • Osmotic
Drug Induced Kidney ... Vitamin C • Glomerular ... : Drug induced vasculitis ... differential #diagnosis #algorithm
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