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differential rheumatology hematology nephrology workup dermatology neurology aki management skinrash testing acute classification disease glomerular glomerulonephritis huv injury kidney nephrotic
Diagnosis and Management of Hypocomplementemic Urticarial Vasculitis (HUV) Diagnosis of HUV 1) Chronic urticaria 2) Leukocytoclastic vasculitis 3)
Diagnosis and Management ... of Hypocomplementemic ... (HUV) Diagnosis ... 3) Hypocomplementemia ... TerrierBen #Hypocomplementemic
Pathophysiology of Hypocomplementemic Urticarial Vasculitis C1q/anti-C1q antibiody -> Immune Complex Formation - Complement Pathway Activation (C3a and C5a)
Pathophysiology of Hypocomplementemic ... Urticarial Vasculitis ... Complex Formation - Complement ... Formation -> Vasculitis ... TerrierBen #Hypocomplementemic
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
Causes of Hypocomplementemia ... @AnnKumfer #Hypocomplementemia ... #Low #Complement ... CHAMPS #Mnemonic #diagnosis
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
- Differential Diagnosis ... tract, and often causes ... often involved • Hypocomplementemic ... Urticaria and hypocomplementemia ... against MPO • Complement
IgG4-Related Disease Clinical history: Man, 60 years, multiorgan involvement, unique or multiple inflammatory pseudotumor 4 phenotypes: •
pseudotumor 4 phenotypes ... PET-CT Imaging (→ Diagnostic ... rheumatoid factor), ± hypocomplementemia ... No necrosis, No vasculitis ... #management #phenotypes
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Diagnosis Framework ... Differential Diagnosis ... tract, and often causes ... Elevated AST ALT • Hypocomplementemia ... ) • Hypocomplementemic
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
pathophysiologic causes ... staining): • Low Complement ... Glomerulonephritis #Vasculitis ... #differential #diagnosis ... #algorithm #rheumatology
Vascular Skin Lesions - Differential Diagnosis Algorithm - Petechiae < 0.2 cm diameter - Purpura 0.2
- Differential Diagnosis ... Algorithm - Petechiae ... #Vascular #Vasculitis ... #Differential #Diagnosis ... #Algorithm #causes
Causes of Peripheral Weakness with Sensory Changes - Differential Diagnosis Algorithm Radiculopathy: • Disc • Spondylosis •
Causes of Peripheral ... - Differential Diagnosis ... Algorithm Radiculopathy ... Multiplex: • Vasculitis ... #Algorithm #Causes
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Causes of Thrombocytopenia ... - Differential Diagnosis ... Algorithm Decreased ... HUS • DIC • Vasculitis ... #Algorithm #Causes
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