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management differential rheumatology hematology criticalcare fever foamed lupus table antibiotics cardiology classification clinical comparison disease druginduced febrile infant lp pediatrics
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
Causes of Hypocomplementemia ... @AnnKumfer #Hypocomplementemia ... #Low #Complement ... CHAMPS #Mnemonic #diagnosis
IgG4-Related Disease Clinical history: Man, 60 years, multiorgan involvement, unique or multiple inflammatory pseudotumor 4 phenotypes: •
pseudotumor 4 phenotypes ... with response to treatment ... rheumatoid factor), ± hypocomplementemia ... #management #phenotypes ... #workup #treatment
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
- Differential Diagnosis ... often involved • Hypocomplementemic ... Urticaria and hypocomplementemia ... against MPO • Complement ... (Low levels mixed
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
staining): • Low ... Complement: Post-strep ... Idiopathic • Normal Complement ... #differential #diagnosis ... #algorithm #rheumatology
Graves Hyperthyroidism - Diagnosis and Management Algorithm Low TSH -> TSH-R-Ab+ -> Graves' Hyperthyroidism doi: 10.1210/clinem/dgaa646 #Graves #Disease #Hyperthyroidism
Hyperthyroidism - Diagnosis ... and Management Algorithm ... Low TSH -> TSH-R-Ab ... Hyperthyroidism #Management #Algorithm ... #treatment #diagnosis
Shock - Differential Diagnosis Framework - MAP <65. SBP <90, drop in SBP > 40 -
- Differential Diagnosis ... 1.5 High CO / Low ... Spinal Cord Injury Low ... #criticalcare #algorithm ... #treatment #management
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
- Differential Diagnosis ... Algorithm Hodgkin ... B-Cell ~90% • Low ... Responsive to Treatment ... #differential #algorithm
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Erythematosus (SLE) - Diagnosis ... 60-80% - Low ... complement - 50 ... life-threatening • Treatment ... Erythematosus #Diagnosis
Complement Deficiency Testing Algorithm • Normal CH50 and AH50 AND High suspicion for complement deficiency •
Complement Deficiency ... Testing Algorithm ... deficiency • Low ... Deficiency #Testing #Algorithm ... #hematology #diagnosis
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
in >90% - Low ... complement - Rare ... 60-80% - Low ... complement - 50 ... #rheumatology #diagnosis
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