14 results
diagnosis differential hematology causes rheumatology testing vasculitis anemia hemolytic pathophysiology allergy c1inh c5c9deficiency celiac champs classification dermatology disease erythematosus esterase
Pathophysiology of Hypocomplementemic Urticarial Vasculitis C1q/anti-C1q antibiody -> Immune Complex Formation - Complement Pathway Activation (C3a and C5a)
Pathophysiology of Hypocomplementemic ... Complex Formation - Complement ... TerrierBen #Hypocomplementemic
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
Causes of Hypocomplementemia ... @AnnKumfer #Hypocomplementemia ... #Low #Complement
C5-C9 Deficiency - Pathogenesis and Clinical Findings Note: • Risk of invasive meningococcal disease is 1000-10000x higher
C5-C9 Deficiency ... higher in C5-C9 deficiency ... is rare Normal complement ... response: The complement ... tissue -> Fatigue, fever
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
often involved • Hypocomplementemic ... Urticaria and hypocomplementemia ... Coronary arteries - Fever ... Vasculitis: • Fevers ... against MPO • Complement
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Differential Diagnosis Algorithm ... Defects • G6PD deficiency ... • PK deficiency ... perfringens - Complement-Mediated ... Differential #Diagnosis #Algorithm
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Vasculitis: • Fevers ... and branches • Fever ... Coronary arteries • Fever ... Elevated AST ALT • Hypocomplementemia ... Vasculitis) • Hypocomplementemic
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Differential Diagnosis Algorithm ... ' nucleotidase deficiency ... , Hexokinase deficiency ... bartonella (oroya fever ... Differential #Diagnosis #Algorithm
Complement Deficiency Testing Algorithm • Normal CH50 and AH50 AND High suspicion for complement deficiency •
Complement Deficiency ... Testing Algorithm ... suspicion for complement ... deficiency • Low ... #Algorithm #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm Hereditary: • Peripheral blood smear + DAT + further History •
Differential Diagnosis Algorithm ... DAT (-) → G6PD Deficiency ... Recent travel/Fevers ... Differential #Diagnosis #Algorithm
Complement 1 esterase inhibitor (C1-INH) Deficiency Testing Algorithm INDICATIONS FOR TESTING: • Recurrent angioedema (without urticaria) •
Complement 1 esterase ... inhibitor (C1-INH) Deficiency ... Testing Algorithm ... ARUPLabs #C1INH #Complement ... #Testing #Algorithm
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