14 results
diagnosis differential causes hematology anemia hemolytic rheumatology vasculitis classification hemolysis intravascular agglutinin champs cord disorders iga low management mnemonic nephropathy
Pathophysiology of Hypocomplementemic Urticarial Vasculitis C1q/anti-C1q antibiody -> Immune Complex Formation - Complement Pathway Activation (C3a and C5a)
Pathophysiology of Hypocomplementemic ... Complex Formation - Complement ... TerrierBen #Hypocomplementemic ... Urticarial #Vasculitis #HUV
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Differential Diagnosis Algorithm ... Warm AIHA • Cold ... perfringens - Complement-Mediated ... • Cold AIHA ... MAHA (TTP, DIC, HUS
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
Causes of Hypocomplementemia ... Chain deposition disease ... A - Atypical HUS ... @AnnKumfer #Hypocomplementemia ... #Low #Complement
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
uremic syndrome (HUS ... Autoimmune (AIHA)"Cold ... (e.g. primary cold ... agglutin disease ... e.g. sickle cell disease
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
often involved • Hypocomplementemic ... Urticaria and hypocomplementemia ... against MPO • Complement ... Cryoglobulins • HIV ... • HBV HCV •
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Disease 3 Types ... Agglutinin Disease ... Mycoplasma, EBV, HIV ... temperatures by fixing complement ... the RBCs causing intravascular
Causes of Secondary IgA Nephropathy - Differential Diagnosis Algorithm • GI disorders: Celiac disease, Crohn's disease,
Differential Diagnosis Algorithm ... , Crohn's disease ... NASH • Viruses: HIV ... Pulm disorders: COPD ... Differential #Diagnosis #Algorithm
Differential Diagnosis for Hemolytic Anemia Intrinsic Causes: • Enzyme deficiencies ex. G6PD, pyruvate kinase • Hemoglobinopathies
Causes: • Liver disease ... • AIHA: warm, cold ... IVIG infusion Intravascular ... • MAHA: TTP, HUS
Causes of Pulmonary Hypertension - Differential Diagnosis Algorithm Pulmonary Arterial Hypertension • Idiopathic • Associated with:
Differential Diagnosis Algorithm ... Connective Tissue Disease ... - HIV Left-Sided ... Hypoxemia: • COPD ... Differential #Diagnosis #Algorithm
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Differential Diagnosis Algorithm ... Agglutination - Cold ... agglutinins disease ... DIC, TTP, HELLP, HUS ... Differential #Diagnosis #Algorithm
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