22 results
Pathophysiology of Hypocomplementemic Urticarial Vasculitis

C1q/anti-C1q antibiody ->
Immune Complex Formation - Complement Pathway Activation (C3a and C5a)
Pathophysiology of Hypocomplementemic ... Complex Formation - Complement ... TerrierBen #Hypocomplementemic ... Urticarial #Vasculitis #HUV
Causes of Hypocomplementemia - CHAMPS Mnemonic
C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis
H - Heavy Chain deposition
Causes of Hypocomplementemia ... A - Atypical HUS ... @AnnKumfer #Hypocomplementemia ... #Low #Complement ... Mnemonic #diagnosis #differential
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm
Extravascular - Spleen and RES-mediated hemolysis
 -
Diagnosis Algorithm ... Warm AIHA • Cold ... perfringens - Complement-Mediated ... • Cold AIHA ... MAHA (TTP, DIC, HUS
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
Vasculitides - Differential ... often involved • Hypocomplementemic ... Urticaria and hypocomplementemia ... against MPO • Complement ... • HBV HCV •
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Positive Coombs testing ... post infectious setting ... Mycoplasma, EBV, HIV ... younger pts) Differential ... temperatures by fixing complement
Autoimmune Hemolytic Anemia (AIHA)

WARM AHA
- Primary - Idiopathics
- Secondary
Infectious
 • Viral- HIV, EBV, HCV, HEV
 •
Infectious • Viral- HIV ... , EBV, HCV, HEV ... alpha-methyldopa COLD ... AIHA #Diagnosis #Differential ... #Algorithm
Hemolytic Anemia - Differential Diagnosis Algorithm
 • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia - Differential ... Diagnosis Algorithm ... Agglutination - Cold ... DIC, TTP, HELLP, HUS ... workup #hematology #testing
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
Platelet Disorders - Differential ... , HCV - Alcohol ... practices that could ... /HCV testing - ... Platelet #Disorders #Differential
Causes of Secondary IgA Nephropathy - Differential Diagnosis Algorithm
 • GI disorders: Celiac disease, Crohn's disease,
Nephropathy - Differential ... Diagnosis Algorithm ... NASH • Viruses: HIV ... Pulm disorders: COPD ... #Diagnosis #Algorithm
Causes of Acute Kidney Injury (AKI) - Differential Diagnosis Algorithm
Acute Kidney Injury (AKI) - Acute increase
Injury (AKI) - Differential ... Diagnosis Algorithm ... Shiga-like toxin (E. coli ... KidneyInjury #Nephrology #Differential ... #Diagnosis #Algorithm