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diagnosis differential anemia hemolytic rheumatology vasculitis agglutinin autoimmune causes champs classification disease extravascular hemolysis intravascular low mnemonic pathophysiology urticarial vasculitides
Pathophysiology of Hypocomplementemic Urticarial Vasculitis C1q/anti-C1q antibiody -> Immune Complex Formation - Complement Pathway Activation (C3a and C5a)
Pathophysiology of Hypocomplementemic ... Complex Formation - Complement ... TerrierBen #Hypocomplementemic ... Urticarial #Vasculitis #HUV ... Pathophysiology #Rheumatology
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
Causes of Hypocomplementemia ... A - Atypical HUS ... @AnnKumfer #Hypocomplementemia ... #Low #Complement ... #differential #hematology
Warm vs Cold Autoimmune Hemolytic Anemia Warm Autoimmune Hemolytic Anemia: • Mechanism: IgG and Complement-mediated • Etiology:
Mechanism: IgG and Complement-mediated ... Mechanism: IgM and Complement-mediated ... disorder, Mycoplasma, HIV ... Hemolytic #Anemia #hematology ... #diagnosis #comparison
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Warm AIHA • Cold ... perfringens - Complement-Mediated ... • Cold AIHA ... MAHA (TTP, DIC, HUS ... #Causes #Hematology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Positive Coombs testing ... post infectious setting ... Mycoplasma, EBV, HIV ... temperatures by fixing complement ... hemolytic #anemia #hematology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
often involved • Hypocomplementemic ... Urticaria and hypocomplementemia ... against MPO • Complement ... • HBV HCV • ... differential #diagnosis #rheumatology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Differential Diagnosis Algorithm ... Agglutination - Cold ... DIC, TTP, HELLP, HUS ... #workup #hematology ... #testing
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