9 results
Diagnosis and Management of Hypocomplementemic Urticarial Vasculitis (HUV)

Diagnosis of HUV
1) Chronic urticaria 
2) Leukocytoclastic vasculitis 
3)
Management of Hypocomplementemic ... (HUV) Diagnosis ... urticaria 2) ... vasculitis 3) Hypocomplementemia ... TerrierBen #Hypocomplementemic
Pathophysiology of Hypocomplementemic Urticarial Vasculitis

C1q/anti-C1q antibiody ->
Immune Complex Formation - Complement Pathway Activation (C3a and C5a)
Pathophysiology of Hypocomplementemic ... Urticarial Vasculitis ... Complex Formation - Complement ... TerrierBen #Hypocomplementemic ... #HUV #Pathophysiology
Causes of Hypocomplementemia - CHAMPS Mnemonic
C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis
H - Heavy Chain deposition
Causes of Hypocomplementemia ... A - Atypical HUS ... @AnnKumfer #Hypocomplementemia ... #Low #Complement
Complement 1 esterase inhibitor (C1-INH) Deficiency Testing Algorithm
INDICATIONS FOR TESTING:
 • Recurrent angioedema (without urticaria)
 •
Complement 1 esterase ... Algorithm INDICATIONS ... angioedema (without urticaria ... ARUPLabs #C1INH #Complement ... #Algorithm #allergy
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
often involved • Hypocomplementemic ... Urticarial Vasculitis ... and hypocomplementemia ... against MPO • Complement ... • HBV HCV •
Alpha-gal Syndrome (AGS) - Diagnosis Algorithm
Does patient have recurrent episodes of urticaria, angioedema or isolated GI
AGS) - Diagnosis Algorithm ... recurrent episodes of urticaria ... then consider testing ... AGS #Diagnosis #Algorithm ... #allergy
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
HTN • Check: HBV ... Elevated AST ALT • Hypocomplementemia ... : Urticarial Vasculitis ... Vasculitis) • Hypocomplementemic ... Urticarial Vasculitis
Blood Product Transfusions One Pager Summary
Type and screen - determines blood type and detects in recipient
Crossmatch - involves testing ... - Allergic ... S/sx urticaria, ... false negatives on testing ... 2,000,000,000, HBV
Blood Transfusion Reactions

Immune Mediated:
 • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
• Allergic reaction ... S/sx urticaria, ... false negatives on testing ... 2,000,000,000, HBV ... in 100,000,000, HCV