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diagnosis rheumatology vasculitis causes erythematosus hematology lupus systemic acidosis agglutinin anemia c3 champs clinicopathology cold criteria cryoglobulinemia cryoglobulins dermatology disease
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
Causes of Hypocomplementemia ... 1 (50%-80%), type ... @AnnKumfer #Hypocomplementemia ... #Low #Complement ... Mnemonic #diagnosis #differential
Effect of Selected Diseases on Complement Levels - C3, C4 • SLE C3 ↓ C4 ↓↓
Selected Diseases on Complement ... • SLE C3 ↓ C4 ... ↓↓ • MCGN type ... ThePeanutKidney #Complement ... #differential #
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus Clinical Domains: • Constitutional domain: Fever • Cutaneous domain: Non-scarring
EULAR/ACR Classification ... anticoagulant • Complement ... Low C3 or low C4 ... Low C3 and low C4 ... #Criteria #SLE
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
diseases: - 10% SLE ... • Low serum C4 ... complement level ... erythematosus (SLE ... #classification
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
often involved • Hypocomplementemic ... Urticaria and hypocomplementemia ... against MPO • Complement ... vasculitis, and SLE ... #rheumatology #classification
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Skin Disease Classification ... permanent alopecia Differential ... Kikuchi disease • Type-I ... levels (C3 and C4 ... activity • C3 C4
Types of Melanoma Superficial Spreading • Most common form • Often develops in previously benign mole •
Types of Melanoma ... • Most common type ... eye you cannot see ... #differential # ... diagnosis #classification
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Vasculitis - Differential ... Vasculitis Differential ... diseases, such as SLE ... Elevated AST ALT • Hypocomplementemia ... Vasculitis) • Hypocomplementemic
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Agglutinin Disease 3 Types ... hemolysis • C3↓ C4 ... younger pts) Differential ... temperatures by fixing complement
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis The most common causes of hyperlactatemia are usually:
Lactic Acidosis - Differential ... are listed as Type ... again we might see ... Acidosis #Elevation #Differential ... #typeb #classification
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