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diagnosis differential workup hemolytic pancytopenia rheumatology agglutinin anorexianervosa causes champs classification complications criteria deficiency disease erythematosus extravascular hemolysis intravascular lupus
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
Causes of Hypocomplementemia ... @AnnKumfer #Hypocomplementemia ... #Low #Complement ... #differential #hematology
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Warm AIHA • Cold ... perfringens - Complement-Mediated ... • Cold AIHA ... immune-complex hemolytic anemia ... #Causes #Hematology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
originate from a low-grade ... • Symptoms of anemia ... Positive Coombs testing ... temperatures by fixing complement ... #hematology #diagnosis
Complement Deficiency Testing Algorithm • Normal CH50 and AH50 AND High suspicion for complement deficiency •
Complement Deficiency ... Testing Algorithm ... deficiency • Low ... #Deficiency #Testing ... #Algorithm #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... Differential Diagnosis Algorithm ... Agglutination - Cold ... #workup #hematology ... #testing
SLICC SLE Diagnostic Criteria - Systemic Lupus Erythematosus Clinical and Immunologic Criteria CLINICAL CRITERIA - ACUTE CUTANEOUS LUPUS
NEUROLOGIC - HEMOLYTIC ANEMIA ... reference range (or 2-fold ... anticoagulant - Low ... complement (C3, ... #Diagnosis #Rheumatology
Pancytopenia - Workup and Differential Diagnosis Algorithm Consumption Disorders 1. Autoimmune Mediated Pancytopenia 2. Splenic Sequestration Peripheral Destruction
Differential Diagnosis Algorithm ... Production - Flow ... Eating disorders ... Acquired Aplastic Anemia ... #Hematology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
often involved • Hypocomplementemic ... Urticaria and hypocomplementemia ... against MPO • Complement ... (Low levels mixed ... differential #diagnosis #rheumatology
Pancytopenia - Workup and Differential Diagnosis Algorithm Consumption Disorders 1. Autoimmune Mediated Pancytopenia 2. Splenic Sequestration Peripheral Destruction
Differential Diagnosis Algorithm ... Production - Flow ... Eating disorders ... Acquired Aplastic Anemia ... #Hematology
Anorexia Nervosa: Complications CARDIAC ABNORMALITIES - Functional: Low BP, Sinus bradycardia, prolonged QT interval - Structural: Reduced
- Functional: Low ... Enzymes - From fasting ... and memory loss HEMATOLOGIC ... lymphocytosis, mild anemia ... Hypothermia and Cold
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