9 results
Pathophysiology of Hypocomplementemic Urticarial Vasculitis

C1q/anti-C1q antibiody ->
Immune Complex Formation - Complement Pathway Activation (C3a and C5a)
Pathophysiology of Hypocomplementemic ... Complex Formation - Complement ... TerrierBen #Hypocomplementemic ... Urticarial #Vasculitis #HUV
Causes of Hypocomplementemia - CHAMPS Mnemonic
C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis
H - Heavy Chain deposition
Causes of Hypocomplementemia ... A - Atypical HUS ... @AnnKumfer #Hypocomplementemia ... #Low #Complement
Effect of Selected Diseases on Complement Levels - C3, C4
 • SLE C3 ↓ C4 ↓↓
Selected Diseases on Complement ... Levels - C3, C4 ... • SLE C3 ↓ C4 ... C3 ↓ C4 → • HUS ... #Levels #C3 #C4
Pulmonary Renal Syndromes and Mimics - Differential Diagnosis Framework
Diffuse alveolar hemorrhage + rapidly progressive glomerulonephritis
90%:
 -
anti-GBM) 10%: - Low Complement ... Levels: SLE, Cryoglobulinemic ... Levels: Scleroderma ... hypertension - MAHA: HUS ... , atypical HUS,
Atypical HUS - Hemolytic Uremic Syndrome
Unlike typical HUS, which is shigatoxin mediated, aHUS is not typically
Unlike typical HUS ... autoimmune like SLE ... It is complement ... need the ADAMTS13 level ... with Eculizumab (complement
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
often involved • Hypocomplementemic ... Urticaria and hypocomplementemia ... against MPO • Complement ... (Low levels mixed ... vasculitis, and SLE
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
diseases, such as SLE ... Vasculitis: • Fevers ... Elevated AST ALT • Hypocomplementemia ... Vasculitis) • Hypocomplementemic
Yamaguchi cardiomyopathy on Echocardiogram (A4C)

ECG has been stable for years, she only feels unwell when in
Yamaguchi cardiomyopathy ... Echocardiogram (A4C) ECG has ... stable for years, she ... only feels unwell ... #Yamaguchi #cardiomyopathy
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Yamaguchi cardiomyopathy on Electrocardiogram (EKG)
That time when a doctor tells you that you're "having a heart
Yamaguchi cardiomyopathy ... ECG has been stable ... for years, she ... only feels unwell ... #Yamaguchi #cardiomyopathy