10 results
diagnosis differential rheumatology management causes champs classification dyspnea glomerulonephritis hematology hemoptysis huv igg4 low mimics mnemonic pathophysiology phenotypes progressive rapidly
Pathophysiology of Hypocomplementemic Urticarial Vasculitis C1q/anti-C1q antibiody -> Immune Complex Formation - Complement Pathway Activation (C3a and C5a)
Pathophysiology of Hypocomplementemic ... Urticarial Vasculitis ... Complex Formation - Complement ... Formation -> Vasculitis ... TerrierBen #Hypocomplementemic
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
Causes of Hypocomplementemia ... Chain deposition disease ... @AnnKumfer #Hypocomplementemia ... #Low #Complement
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
progressing GN • New pulmonary ... glomerulonephritis and/or pulmonary ... often involved • Hypocomplementemic ... Urticaria and hypocomplementemia ... against MPO • Complement
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
progressing GN • New pulmonary ... MPO > PR3) • Pulmonary ... Granulomas, IgE, pulmonary ... Elevated AST ALT • Hypocomplementemia ... ) • Hypocomplementemic
Pulmonary Renal Syndromes and Mimics - Differential Diagnosis Framework Diffuse alveolar hemorrhage + rapidly progressive glomerulonephritis 90%: -
Pulmonary Renal ... - Anti-GBM Disease ... anti-GBM) 10%: - Low Complement ... - Normal Complement ... Kumfer @AnnKumfer #Pulmonary
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
staining): • Low Complement ... With associated pulmonary ... involvement: Anti-GBM Disease ... Glomerulonephritis #Vasculitis ... differential #diagnosis #algorithm
Causes of Dyspnea - Differential Diagnosis Algorithm Cardiac: • Dysrhythmia • Ischemia • Cardiomyopathy • Valvular disease
Differential Diagnosis Algorithm ... disease • Asthma ... Interstitial lung disease ... hypertension • Vasculitis ... Differential #Diagnosis #Algorithm
Hemoptysis Differential Diagnosis Framework Cardiovascular: Pulmonary embolism, Heart failure, Vasculitis, Valvular disease, Arteriovenous malformation Pulmonary - Airway: Bronchitis,
Cardiovascular: Pulmonary ... Heart failure, Vasculitis ... , Valvular disease ... Differential #Diagnosis #algorithm ... #pulmonary
IgG4-Related Disease Clinical history: Man, 60 years, multiorgan involvement, unique or multiple inflammatory pseudotumor 4 phenotypes: •
IgG4-Related Disease ... rheumatoid factor), ± hypocomplementemia ... No necrosis, No vasculitis ... IgG4 #Related #Disease
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Cytopenia: 2% • Hypocomplementemia ... : • 10%-15% Pulmonary ... , INC risk PE, Pulmonary ... ) • Cutaneous vasculitis ... : 2% Systemic Vasculitis
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