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diagnosis differential hyperkalemia comparison high management treatment algorithm binding digoxin diuresis diuretics effects excretion hypotonic lactated lr normal ns pathophysiology
Potassium-Binding Agents to Treat Hyperkalemia Sodium zirconium cyclosilicate (Lokelma): • Mechanism: Preferentially captures K in exchange for
Potassium-Binding ... of aspiration #Potassium ... #medications #pharmacology ... #table #comparison ... #binders
Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
lysis syndrome - Rhabdomyolysis ... Medications 2. ... differential #diagnosis #causes ... #potassium #high ... #nephrology
Digoxin Pharmacology and Pathophysiology 1) Na/K ATPase Pump - Digoxin works by directly binding to and inhibiting
Digoxin Pharmacology ... intracellular calcium causes ... Because digoxin binds ... (or low potassium ... Pathophysiology #cardiology
Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
lysis syndrome - Rhabdomyolysis ... Medications 2. ... differential #diagnosis #causes ... #potassium #high ... #nephrology
Hyperkalemia - Diagnosis and Management - GrepMed Handbook S/Sx: Most pts asymptomatic. Weakness, cramping, nausea, paresthesias, palpitations,
Etiology: • Medications ... Elimination (see Table ... acidosis) • Low ... Management #Treatment #potassium ... #nephrology #K
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary Causes of Rhabdomyolysis: • Trauma: - Immobilization - Crush injury - Compartment
Management Summary Causes ... Hyperuricemia • Hyponatremia ... Monitor potassium ... per day until stable ... #treatment #nephrology
Physiologic Approach to Hypotonic Hyponatremia The next time you have a case of hypotonic hyponatremia, give the
time you have a case ... algorithm Urine Na+K ... Present (Uosm ≥100): Hypovolemia ... differential #diagnosis #table ... #sodium #nephrology
Lactated Ringers (LR) vs Normal Saline (NS) - Comparison Composition of LR: • Sodium 130 mEq/L •
130 mEq/L • Potassium ... trial • Minimal K ... Is Dangerous in Hyperkalemia ... • Saline May Cause ... NS #comparison #pharmacology
Pragmatic diagnostic algorithm for hypokalemia. ***Typical presentations: • Vomiting: urine Na/Cl > 1.6, low urine
urine Na/Cl > 1.6, low ... Tubulopathy: urine K/ ... correcting serum potassium ... Other medications ... differential #algorithm #nephrology
Diuretics and Agents Regulating Renal Excretion Carbonic Anhydrase Inhibitors (Acetazolamide, Dichlorphenamide) • Glaucoma • Epilepsy • Altitude
Kidney stones caused ... and euvolemic hyponatremia ... Excretion #Diuresis #Nephrology ... #Pharmacology # ... Medications #Table
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