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hematology causes coagulation oncology syndrome adultonset apml aptt classification differentiation disease disseminated fungal hodgkins infections infectiousdiseases intravascular lymphoma macrophage mycoses
Adult-Onset Still's Disease Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia + Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
fraction < 20% Differential ... Complications: MAS ... , Visceral, DIC, ... #management #treatment ... #rheumatology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
protein C and S Pathophysiology ... • Severe Liver ... #Coagulation #diagnosis ... #causes #treatment ... #management #hematology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
thrombocytopenia • Liver ... 10,000 ng/mL • Hyponatremia ... #Syndrome #Diagnosis ... #Management #Hematology ... #Rheumatology
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Causes of Abnormal ... intravascular coagulation (DIC ... Prolonged #Causes #diagnosis ... #differential # ... hematology #coagulation
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Triggers: ATRA treatment ... Pathophysiology ... initiation • Differential ... 500 mg QD until normal ... #management #hematology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
lymph node biopsy (diagnostic ... Immunohistochemical studies (to differentiate ... Hodgkin Lymphoma Treatment ... classification #hematology ... #oncology #management
Mycoses HISTOPLASMOSIS • Inhalation of conidia → Yeast → travel to lymph nodes → spread in body • Bird
pulmonary symptoms • Rheumatologic ... Mississippi and Ohio River ... level • A low or normal ... Aspergillosis Pathophysiology ... #Management #Infections
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