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diagnosis liver causes hematology algorithm injury management apml bandemia biliary chemistry children cholangitis cirrhosis coagulation dic differentiation disseminated epilepticus hepatitis
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
Liver Injury - Differential ... Vasculature • Hepatic ... Congestion/CHF • Hepatic ... Malignancy, 1° PBC ... #algorithm #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
- Differential ... Liver Injury: • Hepatic ... Venoocclusive disease • Hepatic ... injury #hepatitis #differential ... diagnosis #algorithm #hepatology
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
) - Summary PBC ... Pathophysiology ... bile ducts Differential ... malignancies, Hepatic ... diagnosis #workup #hepatology
Bandemia Overview Normal: < 1% Clinically significant: > 10% Band neutrophils are slightly less mature than segmented neutrophils and
Neutrophil (Normal) Differential ... hypotension or septic ... #Bandemia #differential ... #CBC #hematology ... #pathophysiology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Hepatocellular - Check Acute ... Mixed - Check Acute ... replaced by non-hepatic ... chemistry #diagnosis #differential ... #Hepatology #transaminitis
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
malignancy (Especially acute ... protein C and S Pathophysiology ... 100mg/dL) - Heparin ... hydration • RBC ... treatment #management #hematology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
ATRA treatment Pathophysiology ... • Rare: DAH, acute ... initiation • Differential ... , Anaphylaxis, Acute ... diagnosis #management #hematology
Pyogenic liver abscess in children Common bacterial causes in children: • S.aureus • Strep spp • Enteric
Pyogenic liver abscess ... through: - Hepatic ... #pediatrics #children ... #peds #differential ... #diagnosis #hepatology
Causes of Status Epilepticus in Adults METABOLIC DISTURBANCES Hepatic encephalopathy Hypocalcemia Hypoglycemia or hyperglycemia Hyponatremia Uremia INFECTIOUS PROCESSES Central nervous system abscess Encephalitis Meningitis WITHDRAWAL SYNDROMES Alcohol Antiepileptic drugs Baclofen Barbiturates Benzodiazepines CENTRAL
DISTURBANCES Hepatic ... hyperglycemia Hyponatremia ... nervous system abscess ... SYSTEM LESIONS Acute ... Epilepticus #Seizures #Differential
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