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diagnosis treatment differential algorithm hepatology syndrome hemophagocytic lymphohistiocytosis arthritis lupus sle summary anemia aosd blood classification comparison erythematosus gastroenterology liver
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
, ↓ Fibrinogen level ... • Autoimmune diseases ... Drugs, Unknown cause ... Lymphohistiocytosis #diagnosis #management ... treatment #summary #rheumatology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
lymphohistiocytosis (HLH ... highly inflammatory disease ... hypersensitivity syndromes • HLH ... Syndrome #Diagnosis #Management ... #Hematology #Rheumatology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
Diagnosis and Workup ... disease, decrease ... disease), HBsAg ... a primary hematologic ... #Workup #hematology
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
age, however the disease ... following: • Fever ... If no response HLH ... Lymphohistiocytosis #diagnosis #management ... #treatment #hematology
Algorithm regarding the diagnosis and treatment of Hereditary Hemochromatosis HH. Step 1: In the patient with
out additional causes ... of liver disease ... and hematologic ... If other causes ... algorithm #diagnosis #management
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Diagnosis and Management ... • Immunologic Workup ... Positive in 60-80% of cases ... Evolution: Chronic disease ... #Summary #rheumatology
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Causes of Anemia ... • Pancreatic Disease ... Disease #Macrocytic ... Diagnosis #Algorithm #Causes ... #Hematology
Cold Urticaria Prevalence - 0.05% in the population Disease onset - Mostly 2nd to 4th decades of life Causes
4th decades of life ... Causes and clinical ... symptoms - Headache, fever ... , fatigue, Nausea ... Urticaria #diagnosis #rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) Treatment Primary HLH: - HLH-94 Protocol • Dexamethasone
or autoimmune disease ... Options for severe cases ... for refractory disease ... #Treatment #management ... #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Consider sickle cell disease ... RBC inclusions - If ... bartonella (oroya fever ... Diagnosis #Algorithm #workup ... #hematology #testing
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